Description

Sigan (nimesulide, dicycloverine) Coated Tablets №4

Ingredients

Active ingredients: Each coated tablet contains nimesulide and dicycloverine.

Dosage

Dosage: The usual recommended dose is one tablet taken orally twice daily.

Indications

Indications: Sigan tablets are indicated for the relief of symptoms associated with irritable bowel syndrome (IBS) and mild to moderate pain.

Contraindications

Contraindications: Do not use Sigan tablets in patients with a history of hypersensitivity to nimesulide, dicycloverine, or any other component of the formulation.

Directions

Directions: Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.

Scientific Evidence

Nimesulide, a nonsteroidal anti-inflammatory drug (NSAID) present in Sigan tablets, exerts its pharmacological effects by inhibiting cyclooxygenase (COX) enzymes, thereby reducing the production of prostaglandins that mediate inflammation, pain, and fever. Dicycloverine, an antispasmodic agent, acts on smooth muscle in the gastrointestinal tract, relieving spasms and cramps associated with IBS.

Clinical trials have demonstrated the efficacy of nimesulide in managing pain and inflammation, while dicycloverine has shown effectiveness in alleviating gastrointestinal spasms. The combination of these two active ingredients in Sigan tablets provides a synergistic approach to treating the symptoms of IBS and pain.

Additional Information

• Storage: Store Sigan tablets in a cool, dry place away from direct sunlight.
• Side Effects: Common side effects may include nausea, dizziness, and dry mouth. Consult a healthcare professional if any adverse reactions occur.