Description

Siofor 850 (Metformin Hydrochloride) Coated Tablets 850 mg. №60

Ingredients

Active ingredient: Metformin hydrochloride 850 mg.

Dosage

Dosage: The usual starting dose is 500 mg or 850 mg once daily with meals. Dosage can be adjusted based on blood glucose levels.

Indications

Indications: Siofor 850 is indicated for the treatment of type 2 diabetes mellitus in adults, particularly in overweight patients.

Contraindications

Contraindications: Do not use in patients with severe renal impairment, metabolic acidosis, or hypersensitivity to metformin.

Directions

Directions: Swallow the tablets whole with a glass of water during or after meals to reduce gastrointestinal side effects.

Scientific Evidence

Metformin’s efficacy: Metformin, the active ingredient in Siofor 850, is a first-line medication for type 2 diabetes due to its proven efficacy in lowering blood glucose levels and improving insulin sensitivity.

Pharmacological effects: Metformin works by decreasing glucose production in the liver, increasing glucose uptake in muscles, and improving insulin utilization, leading to better blood sugar control.

Additional Information

Clinical trials: Clinical studies have shown that metformin not only lowers blood sugar levels but also reduces the risk of cardiovascular complications in diabetic patients.

Comparative effectiveness: Compared to other oral antidiabetic drugs, metformin has a lower risk of hypoglycemia and weight gain, making it a preferred choice for many healthcare providers.