Sirdalud (tizanidin) tablets 4 mg. №30

Description

Sirdalud (tizanidin) tablets 4 mg. №30

Composition

active substance: tizanidine;

1 tablet contains 2.288 mg or 4.576 mg of tizanidine hydrochloride, corresponding to 2 mg or 4 mg of tizanidine, respectively;

Excipients: lactose anhydrous, microcrystalline cellulose, stearic acid, colloidal anhydrous silica.

Dosage form

Tablets.

Basic physical and chemical properties:

• Sirdalud 2 mg – white or almost white round flat tablets with beveled edges, with a line and the inscription “OZ” on one side of the tablet;
• Sirdalud 4 mg – white or almost white round flat tablets with beveled edges, with crossed lines on one side and the inscription “RL” on the other side of the tablet.

Pharmacotherapeutic group

Central action muscle relaxants.
ATX code M03B X02.

Pharmacological properties

Tizanidine is a central skeletal muscle relaxant / antispasmodic. Its main site of action is the spinal cord. Evidence suggests that by stimulating presynaptic α-2-adrenoceptors, it inhibits the release of stimulating amino acids that stimulate N-methyl-D-aspartate receptors (NMDA receptors). As a result, polysynaptic signaling at the level of the interneuronal connections in the spinal cord, which is responsible for excessive muscle tone, is suppressed and muscle tone is reduced. Sirdalud® is effective both in acute painful muscle spasms and in chronic spasticity of spinal and cerebral origin. It reduces resistance to passive movements, suppresses spasms and clonic convulsions, and improves the strength of active muscle contractions.

Indications

It is used when it is necessary to relieve spasms of the skeletal muscles caused by radiculitis, cervical syndrome, neurological pathologies such as multiple sclerosis, degenerative diseases of the spinal cord, cerebral palsy, chronic myelopathy, circulatory disorders of the brain, etc.
It is also prescribed during the rehabilitation period after operations, in particular, after surgical interventions regarding the displacement of the intervertebral disc, accompanied by rupture of the annulus fibrosus, deforming osteoarthritis of the hip joint. It also effectively relieves pain attacks due to muscle spasms, spasticity due to multiple sclerosis, brain and spinal cord lesions.
Tizanidine, which is a centrally acting muscle relaxant, is able to affect the skeletal muscles, reducing muscle tone. Due to this property, the polysynaptic way suppresses the transmission of excitation, which occurs at the stage of intermediate neurons of the spinal cord.
Has some anesthetic effect. It is able to reduce clonic spasms, convulsions, increases the strength of voluntary contractions of the skeletal muscles.

Contraindications

Not applicable in case of hypersensitivity to tizanidine, or to additional substances. The use of this drug is also contraindicated in severe liver dysfunction; it should not be used in combination with fluvoxamine or ciporfloxacin. Prescribed with caution in elderly patients, due to the likelihood of poor kidney function.

Application during pregnancy and lactation

Clinical research has not been carried out on pregnant women, so there is no complete confidence in the complete safety of its action on a woman and her fetus, although experiments on animals have not revealed any negative consequences. The drug penetrates into breast milk, therefore, lactation should be canceled while taking it.

Method of administration and dosage

If it is necessary to relieve muscle spasm caused by neuralgia, the initial dose is 6 milligrams per day, which is taken in three doses throughout the day. After 3-7 days, it is permissible to increase the dose by 2-4 milligrams. The optimal dosage is from 12 to 24 mg, the maximum is 36 milligrams per day.
For painful muscle spasm, take 2 to 4 mg per day, you can take the same dose at night (with severe spasm).

Overdose

Overdose symptoms were noted when taking more than 400 mg of the drug. There were signs of intoxication, a drop in pressure, manifestations of drowsiness, loss of consciousness up to a coma.
Symptomatic treatment, gastric lavage, and drinking plenty of fluids are recommended.

Side effects

Most often, side effects from the gastrointestinal tract (nausea, diarrhea) are observed, manifestations of muscle weakness, drowsiness may occur. Symptoms may be more severe at higher dosages.