Description

Sodiofolin (Disodium Folinate) Solution for Injections or Infusions 200 mg. 50 mg/ml. 4 ml. №1 Vial

Ingredients:

Each vial contains 200 mg of disodium folinate in a 4 ml solution with a concentration of 50 mg/ml.

Dosage:

The dosage of Sodiofolin should be determined by a healthcare professional based on individual patient factors. It is typically administered via injection or infusion.

Indications:

Sodiofolin is indicated for use as a rescue therapy in combination with high-dose methotrexate in the treatment of osteosarcoma. It is also used in the treatment of megaloblastic anemias due to folic acid deficiency.

Contraindications:

Do not use Sodiofolin in patients with known hypersensitivity to folinic acid or any component of the formulation. Caution is advised in patients with renal impairment.

Directions:

Sodiofolin should be administered under the supervision of a healthcare provider experienced in the use of methotrexate and folinic acid. The solution is for single-use only and should be inspected visually for particulate matter before administration.

Scientific Evidence:

Sodiofolin, a form of folinic acid, acts as a reduced folate, playing a crucial role in nucleotide synthesis and DNA replication. This mechanism of action is particularly important in the context of high-dose methotrexate therapy, where folinic acid rescue is essential to prevent methotrexate-induced toxicity while maintaining its anticancer effects.

Clinical trials have demonstrated the efficacy of Sodiofolin in reducing the toxic effects of methotrexate without compromising its antitumor activity. Research by Howard et al. (2017) highlighted the importance of folinic acid rescue in improving the outcomes of methotrexate-based chemotherapy regimens.

Additional Information:

• Storage: Store Sodiofolin vials in a cool, dry place away from light.
• Adverse Reactions: Common side effects may include nausea, vomiting, and allergic reactions.
• Pregnancy and Lactation: Consult a healthcare provider before using Sodiofolin during pregnancy or breastfeeding.