Solu-medrol (methylprednisolone) powder and solvent for injection 40 mg. 1ml. №1 vial

Description

Solu-medrol (methylprednisolone) powder and solvent for injection 40 mg. 1ml. №1 vial

Composition

active ingredient: methylprednisolone;

1 bottle contains 40 mg or 125 mg or 500 mg or 1000 mg of methylprednisolone in the form of methylprednisolone sodium succinate;

• excipients: for dosages of 125 mg or 500 mg or 1000 mg – sodium dihydrogen phosphate, monohydrate; sodium hydrogen phosphate anhydrous;
• excipients: for a dosage of 40 mg – sodium dihydrogen phosphate, monohydrate; sodium hydrogen phosphate anhydrous; lactose, monohydrate;

solvent for dosages of 40 and 125 mg: water for injection;

solvent for dosages of 500 and 1000 mg: benzyl alcohol (9 mg / ml), water for injection.

Dosage form

Powder and solvent for injection.

Basic physical and chemical properties:

powder: from white to almost white color of the lyophilisate;

• solvent for dosages of 40 and 125 mg: clear, colorless solution;
• solvent for dosages of 500 and 1000 mg: a clear, colorless liquid with a slight odor of benzyl alcohol.

Pharmacological group

Corticosteroids for systemic use.
ATX code H02A B04.

Pharmacological properties

This drug belongs to the group of antimicrobial and antiseptic substances based on corticosteroid components, intended for systemic use.
Methylprednisolone is a synthetic glucorticosteroid used to reduce inflammation by inhibiting the secretion and release of inflammatory mediators. In addition to anti-inflammatory, it also has antiallergic and immunosuppressive effects.
Promotes inhibition of the accumulation of cells (leukocytes, macrophages, etc.) in the inflamed area. Helps reduce capillary permeability.
It has an immunosuppressive effect, affects the balance of electrolytes, contributing to the enhancement of the reabsorption of water and sodium, increasing the release of sodium molecules and hydrogen ions.
Increases protein catabolism, glucose and lipid acid levels in the blood, affects the metabolism of amino acids.
Its use also reduces the likelihood of scar tissue formation as it reduces collagen production.

Indications

This drug Solu-medrol powder is used when a glucocorticoid is needed. In particular, during therapy:

• acute allergic reactions;
• bronchial asthma and status asthma;
• shock, incl. resistant to other therapy;
• myocardial infarction;
• acute adrenal insufficiency;
• cirrhosis of the liver;
• acute hepatitis;
• acute hepatic renal failure;
• poisoning with cauterizing liquids (in order to reduce inflammation and prevent cicatricial narrowing).

Also used for the prevention or treatment of thyrotoxic reaction and thyrotoxic crisis, some oncological, endocrine, dermatological, hematological and neurological diseases, eye diseases, pericarditis, and to prevent transplant rejection during organ transplantation. Effective for intra-articular administration in the treatment of arthrosis, arthritis, and other joint diseases.

Contraindications

You should not use the specified drug if the patient has had a previous hypersensitivity (allergy) with respect to one of the components that are part of the drug – both main and auxiliary.
Contraindicated in:

• stomach ulcer and 12 duodenal ulcer;
• Cushing’s syndrome, hypothyroidism, thyrotoxicosis, diabetes mellitus;
• osteoporosis, myasthenia gravis;
• chickenpox;
• diabetes mellitus;
• predisposition to thromboembolism, myocardial infarction;
• renal failure;
• severe arterial hypertension;
• simple and herpes zoster;
• during the vaccination period.

Application during pregnancy and lactation

Treatment of pregnant women in the first trimester is carried out with great care, only according to indications, since there is a risk of impaired fetal growth or complications from the adrenal glands.
In the II and III trimester, as well as during breastfeeding, treatment with this drug is allowed, since it enters the bloodstream in doses that are safe for the mother and child.

Method of administration and dosage

Solu-medrol powder is administered intramuscularly, intravenously, or as an infusion (dropper).
The dosage and duration of treatment is determined by the attending physician. The minimum dosage is from 0.5 mg per 1 kg of the patient’s weight mg per day, depending on the type and severity of the disease. The average dosage is 30 mg per 1 kg of patient weight.
In particular, in case of shock, a dosage is administered at the rate of 30 mg per 1 kg of body weight (in children, from 1 to 3 mg per 1 kg of the patient’s body weight). The introduction is slow, within 30-60 minutes. The course of treatment should not last longer than 72 hours due to the risks of systemic side effects.
Sodium chloride or glucose is used as a solvent.
It should be noted that it is forbidden to suddenly stop the course of treatment, especially if the course was long. In this case, the treatment is discontinued with a gradual decrease in the frequency of administration and dosage size.

Overdose

An overdose of this drug can cause increased side effects and edema.
In general, symptomatic treatment is recommended.

Side effects

The drug is usually well tolerated. Side effects can occur only with prolonged use of the drug.
In this case, you may observe:

• convulsions, increased intracranial pressure;
• Cushing’s syndrome, growth suppression in children, menstrual irregularities, hyperglycemia, glucosuria, decreased carbohydrate tolerance;
• cataract, glaucoma, exophthalmos;
• leukocytosis;
• thrombosis;
• anaphylactic reactions, hypersensitivity reactions, arteritis obliterans, weight gain due to increased appetite, fainting;
• cataract, glaucoma;
• bronchospasm;
• relapse of tuberculosis.