Description

Stoperan (loperamide) hard capsules 2 mg. №8

Ingredients:

Each hard capsule contains 2 mg of loperamide hydrochloride.

Dosage:

The usual adult dosage is 2 capsules initially, followed by 1 capsule after each loose stool. Do not exceed 4 capsules in a 24-hour period.

Indications:

Stoperan is indicated for the symptomatic treatment of acute diarrhea. It helps reduce the frequency of bowel movements and the urgency of diarrhea.

Contraindications:

Do not use Stoperan in patients with a known hypersensitivity to loperamide or in the presence of abdominal distension without diarrhea.

Directions:

Swallow the capsules whole with water. Do not chew the capsules. Consult a healthcare professional if diarrhea persists after 2 days of treatment.

Scientific Evidence:

Loperamide, the active ingredient in Stoperan, is a synthetic opioid that acts on the mu-opioid receptors in the gut, slowing down gut motility and increasing the absorption of water and electrolytes. This mechanism helps to decrease the frequency of diarrhea and improve stool consistency.

Additional Information:

It is important to stay well hydrated while using Stoperan to prevent dehydration due to fluid loss from diarrhea. Avoid using Stoperan in cases of bloody diarrhea or high fever, as it may indicate a more serious condition requiring medical attention.

Pharmacological Effects:

Loperamide exerts its antidiarrheal effects by inhibiting peristaltic activity in the intestinal wall, thereby prolonging gastrointestinal transit time and increasing the reabsorption of fluids and electrolytes. This results in firmer stools and a reduction in the frequency of bowel movements.

Clinical Trials and Research:

Studies have shown that loperamide is effective in reducing the symptoms of acute diarrhea and can provide rapid relief. A study published in the “Journal of Travel Medicine” demonstrated the efficacy of loperamide in treating travelers’ diarrhea, with a significant decrease in the duration and severity of symptoms compared to a placebo group.

• Study: Randomized, double-blind trial on the efficacy of loperamide in acute diarrhea.
• Results: Loperamide was found to significantly reduce the number of watery stools and the duration of diarrhea compared to placebo.