Sulperazon (sulbactam, cefoperazone) powder for solution for injections 500 mg/500 mg. 1 g. vial №1

Description

Sulperazon (sulbactam, cefoperazone) powder for solution for injections 500 mg/500 mg. 1 g. vial №1

Composition

active substances: sulbactam / cefoperazone;

1 vial contains 623 mg of sulbactam sodium, equivalent to 500 mg of sulbactam, and 623 mg of cefoperazone sodium, equivalent to 500 mg of cefoperazone;

1 vial contains 1246 mg of sodium sulbactam, equivalent to 1000 mg of sulbactam, and 1246 mg of cefoperazone sodium, equivalent to 1000 mg of cefoperazone.

Excipients: none.

Dosage form

Powder for solution for injection.

Basic physical and chemical properties: powder from white to almost white color, which does not contain foreign particles.

Pharmacotherapeutic group

Antibacterial agents for systemic use. Other beta-lactam antibiotics. Cephalosporins of the third generation.
ATC code J01D D62.

Pharmacological properties

Sulperazon powder for solution is a combination of sulbactam sodium and cefoperazone sodium.

Sulbactam sodium is a derivative of the main penicillin nucleus. It is an irreversible beta-lactamase inhibitor and is used only parenterally. By chemical structure it is a sulfone of sodium penicillinate. Contains 92 mg of sodium (4 mEq) per 1 gram. Sulbactam is a very easily soluble, almost white crystalline powder. The molecular weight is 255.22.

Cefoperazone sodium is a semi-synthetic cephalosporin antibiotic of the third generation with a broad spectrum of action, which is used only parenterally. Contains 34 mg of sodium (1.5 mEq) per 1 gram. Cefoperazone is a white water-soluble crystalline powder. The molecular weight is 667.65.

Indications

An antibiotic with a pronounced bactericidal effect. It is used as a medicine for infectious diseases of various organs, for example, for the treatment of infections of the respiratory and genitourinary systems. In addition, the drug is effective if the abdominal and pelvic organs, skin and soft tissues, the musculoskeletal system are affected by infections, as well as in meningitis and septicemia.
It has a pronounced bactericidal effect due to active active ingredients – sulbactam, which contains a penicillin nucleus and has the ability to irreversibly inhibit beta-lactamase and cefoperazou, a synthetic antibiotic of the cephalosporin group, capable of inhibiting the synthesis of mucopeptides of microorganism cell membranes. Due to the presence of sulbactam, the activity of the drug is 400% higher than that of pure cefoperazone. In general, the drug is active against gram-positive and gram-negative aerobic and anaerobic bacteria.

Contraindications

It is not prescribed for an allergic reaction to one of the active substances of the drug.
It should be prescribed with caution if the patient is diagnosed with impaired renal or liver function, obstructive diseases of the urinary tract, as well as patients who have been taking parenteral nutrition and anticoagulant treatment for a long time. Contains sodium salts, which should be taken into account with a specific low-sodium diet.
It is prescribed with caution in pediatrics.

Application during pregnancy and lactation

There are no recorded data on the safety of the use of this pharmaceutical product in the treatment of pregnant women. If there is a need for its use during the period when a woman is breastfeeding, lactation should be stopped at this time.

Method of administration and dosage

Sulperazon powder for solution (combination of sodium sulbactam / cefoperazone sodium) is available in vials and is administered parenterally only.

The combination of sulbactam sodium / cefoperazone sodium is presented in the form of a dry powder for reduction in a ratio of 1: 1 in terms of free sulbactam and cefoperazone. Powder vials in a ratio of 1: 1 contain the equivalent of 500 mg + 500 mg and 1000 mg + 1000 mg of sulbactam and cefoperazone, respectively.

Adults. The usual dose of Sulperazone for adults is 2-4 g per day (ie 1 to 2 g of cefoperazone per day) intravenously or intramuscularly in evenly distributed doses every 12 hours.

In severe or refractory infections, the daily dose of Sulperazone can be increased to 8 g (ie the dose of cefoperazone is 4 g) intravenously in evenly distributed doses every 12 hours. The recommended maximum daily dose of sulbactam is 4 g (8 g of Sulperazon powder for solution).

Overdose

There have been no cases of overdose with Sulperazon. In this situation, symptoms should be treated. Hemodialysis is indicated for patients suffering from kidney disease. No antidote has yet been identified.

Side effects

Usually the drug is well tolerated by patients. Possible reactions from the gastrointestinal tract (nausea, vomiting, colitis). The development of jaundice, hyperbilirubinemia is possible.
The composition of the blood may change, in some cases the development of eosinophilia, neutropenia, leukopenia, a decrease in hemoglobin, and a decrease in the period of blood coagulation were noted. Blood pressure may rise.
Allergic skin reactions (pruritus, urticaria) have been reported. There were isolated cases of anaphylactic shock.