Sumamed (azithromycin) capsules 250 mg. №6

Description

Sumamed (azithromycin) capsules 250 mg. №6

Composition

active substance: azithromycin;

1 capsule contains azithromycin 250 mg in the form of dihydrate;

Excipients: microcrystalline cellulose, sodium lauryl sulfate, magnesium stearate, gelatin, titanium dioxide (E 171), indigo carmine (E 132), sulfur dioxide (E 220).

Dosage form

Capsules.

Main physical and chemical properties: hard gelatin capsules № 1 with opaque body of blue color and opaque lid of blue color; capsule content: white to yellowish crystalline powder or white to yellowish lump of crystalline powder.

Pharmacotherapeutic group

Antibacterial agents for systemic use. Macrolides, lincosamides and streptogramins. Azithromycin.
ATX code J01F A10.

Pharmacological properties

Azithromycin is a macrolide antibiotic that belongs to the group of azalides. The molecule is formed by the introduction of a nitrogen atom into the lactone ring of erythromycin A. The mechanism of action of azithromycin is to inhibit bacterial protein synthesis by binding to the 50S subunit of ribosomes and inhibiting peptide translocation.

Indications

Sumamed capsules is an antibiotic with a wide range of antimicrobial action. By binding to the 50S-cytogenetic unit of the ribosome, the drug suppresses the production of proteins in the pathogenic microorganism. In high concentrations, it has a bactericidal effect (kills bacteria). Active against a number of Gr + bacteria:

• Streptococcus agalactiae;
• Streptococcus pneumoniae;
• Streptococcus pyogenes;
• Streptococcus viridans;
• Staphylococcus aureus;
• Clostridium perfringens;
• Staphylococcus epidermidis.

The drug has no effect on Gr-bacteria that are resistant to the antibiotic erythromycin.
Also, this drug is effective against gram-negative microorganisms:

• Haemophilus influenza;
• Moraxella catar-rhalis;
• Haemophilus parainfluenzae;
• Haemophilus ducreyi;
• Bordetella pertussis;
• Helicobacter pylori;
• Gardnerella vaginalis;
• Neisseria meningitides;
• Bordetella parapertussis;
• Neisseria gonorrhoeae;
• Brucella melitensis;
• Campylobacter jejuni.

In addition, the drug is effective against Mycobacterium avium complex, Chlamydia pneumoniae, Legionella pneumophila, Chlamydia trachomatis, Mycoplasma pneumoniae, Listeria monocitogenes, Ureaplasma urealyticum, Borrelia burgdorferi, Treponema pallidum.
Sumamed is prescribed for infections of the upper respiratory tract (tonsillitis, sinusitis, bacterial pharyngitis, otitis media), lower respiratory tract infections (interstitial, alveolar pneumonia, exacerbation of chronic bronchitis, bacterial bronchitis), skin, soft tissues (impetigo, erysipelas, secondary pyodermatosis, initial stage tick-borne borreliosis – erythema migrans), as well as sexually transmitted infections (cervicitis, urethritis), diseases of the stomach / duodenum associated with Helicobacter pylori.

Contraindications

You can not prescribe Sumamed for allergies to antibiotics of the macrolide group, severe liver / kidney dysfunction. This medicine is used with caution in liver / kidney diseases, heart disorders, predisposed to arrhythmias, ECG changes (lengthening of the Q – T interval).

Application during pregnancy and lactation

Perhaps the appointment of Sumamed 250 in these periods for health reasons.

Method of administration and dosage

Sumamed capsules should be taken 1 hour before or 2 hours after a meal, as concomitant use impairs the absorption of azithromycin. Capsules should be swallowed whole. Take the drug once a day.

Adults and children weighing ≥45 kg.

• For infections of the ENT organs and respiratory tract, skin and soft tissues (except for chronic migratory erythema), the total dose of azithromycin is 1500 mg: 500 mg once daily. The duration of treatment is 3 days.
• In migratory erythema, the total dose of azithromycin is 3 g: on the 1st day you should take 1 g (4 capsules in one dose), then 500 mg (2 capsules in one dose) from the 2nd to the 5th day. The duration of treatment is 5 days.
• For sexually transmitted infections: the total dose of azithromycin is 1 g (4 capsules per dose).

If you miss 1 dose of the drug, the missed dose should be taken as early as possible, and the next – at intervals of 24 hours.

Children

Sumamed capsules should be used in children weighing ≥45 kg.

Overdose                                                                                                                                                                Overdose

Symptoms: temporary hearing loss, diarrhea (loose stools), vomiting.
Overdose treatment: urgent gastric lavage, intake of sorbents (for example, activated carbon), symptomatic treatment.

Side effects:

• Disorders of the central nervous system: vertigo (dizziness), convulsions, cephalgia (headache), paresthesia (tingling sensation, crawling creeps, burning sensation on the skin), drowsiness, impotence, insomnia, increased physical activity, aggressiveness, nervousness, anxiety.
• Disorders of the circulatory, lymphatic systems: a decrease in the number of platelets (thrombocytopenia), neutrophilic leukocytes (neutropenia).
• Disorders of the organs of perception: reversible hearing impairment, deafness, tinnitus, impaired perception of taste, smell.
• Digestive tract disorders: stool disorders (constipation, diarrhea), nausea, abdominal pain / cramps, flatulence (bloating), anorexia (lack of appetite), discoloration of the tongue, inflammation of the colon (pseudomembranous colitis), cholestatic jaundice (due to impaired bile outflow) ), hepatitis (liver inflammation), abnormal liver function tests, liver failure, liver necrosis (breakdown), sometimes fatal.
• Disorders of the cardiovascular system: arrhythmia (arrhythmia, palpitations, ventricular (ventricular) tachycardia, widening of the Q-T interval on the ECG, bidirectional ventricular tachycardia).
• Allergic reactions: angioedema (rapid swelling of the face, lips, tongue with impaired breathing), itching, rashes, urticaria, photosensitivity (sensitivity to the sun), anaphylactic shock (fatal in rare cases), erythema multiforme, allergic contact dermatitis.
• Disorders of the genitourinary system: nephritis (inflammation of the kidneys), acute kidney failure.
• Movement disorders: arthralgia (joint pain).
• Others: candidiasis (fungal infection), vaginitis (inflammation of the vagina).