$10.20
Manufacturer: Austria
Prevention and treatment of allergic and pseudoallergic reactions, including reactions to contrast agents, blood transfusions, diagnostic use of histamine.
Secondary treatment (after intramuscular administration of adrenaline at a dose of 0.01 mg / kg) in case of anaphylactic or anaphylactoid shock and angioneurotic edema.
Description
Tavegyl (clemastine) solution for injection 2 mg. 2 ml. ampoules №5
Composition
active substance: clemastine;
1 ml of solution contains clemastine fumarate 1.34 mg, which corresponds to 1 mg of clemastine;
Excipients: sorbitol (E 420), ethanol 96%, propylene glycol, sodium citrate, water for injections.
Dosage form
Solution for injection.
Main physical and chemical properties: clear, colorless or yellowish solution.
Pharmacotherapeutic group
Antihistamines for systemic use.
ATX code R06A A04.
Pharmacological properties
Tavegyl is an H1-receptor antagonist. It belongs to the antihistamines of the group of benzhydryl esters. Tavegil selectively inhibits histamine H1-receptors and reduces capillary permeability. It has a pronounced antihistamine and antipruritic effect, characterized by rapid onset and long duration (up to 12 hours).
Indications
Tavegyl solution for injection is used in the prevention and treatment of pseudo-allergic and allergic reactions, as well as reactions to blood transfusion, administration of a contrast agent or diagnostic use of histamine.
The drug can be used as part of secondary therapy (after the introduction of adrenaline at a dosage of 0.01 mg per kg) of angioedema and anaphylactic or anaphylactoid shock.
In addition, the drug is used in the treatment of pollinosis, urticaria of various origins, itchy dermatoses, acute and chronic eczema, drug allergies, contact dermatitis and insect bites.
Contraindications
Tavegyl is not prescribed for patients undergoing treatment with monoamine oxidase inhibitors. In addition, the drug is not prescribed to patients with lesions of the lower respiratory system, bronchial asthma, intolerance to the components of the drug, severe glucose-galactose malabsorption syndrome, galactose intolerance and severe lactase deficiency. The drug is not used in the treatment of women at the lactation stage. The use of the drug in the form of a solution for parenteral administration is contraindicated for intra-arterial administration, during pregnancy and fructose intolerance. Tavegyl solution and syrup is not used in the treatment of children under one year old, and tablets are not used for children under 6 years old.
With caution, Tavegyl is prescribed to patients who have been found to have a stenosing stomach ulcer, pyloroduodenal obstruction, benign prostatic hypertrophy, complicated by urinary retention, obstruction of the urinary bladder, hyperthyroidism, increased extratrigocular hypodermal pressure, arterial hypertension and arterial hypertension and arterial hypertension.
Application during pregnancy and lactation
Important contraindications for the appointment of Tavegyl are pregnancy and lactation.
Method of administration and dosage
Tavegyl solution is used only for intravenous and intramuscular administration. The solution is injected intravenously slowly. Adult patients receive 2 mg of the drug twice a day. To prevent the occurrence of anaphylactic or a response to the administration of histamine, intravenous administration of 2 mg of the drug directly during the period of their possible occurrence is shown: in the treatment of children, the dose of the drug is calculated at the rate of 0.025 mg of the drug per 1 kg of the child’s body weight per day, divided into two injections.
Overdose
Taking Tavegyl solution in high doses is capable of both depressing and stimulating effects on the human central nervous system. Also, patients may experience dryness of the oral mucosa, fixed dilation of the pupils, rush of blood to the upper body, disruption of the digestive tract.
To eliminate the symptoms of poisoning, the patient is washed with an isotonic sodium chloride solution, saline laxatives are prescribed and symptomatic treatment is prescribed.
Side effects
Taking Tavegyl solution may be accompanied by the development of increased fatigue, drowsiness, sedation, fatigue, impaired coordination of movements, dizziness, tremors of the extremities, dyspeptic disorders, decreased appetite, nasal congestion, palpitations, visual impairment, tinnitus, increased urination, photosensitivity and anaphylactic shock.
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