Description

Tazpen (piperacillin, tazobactam) powder for solution for injections and infusions 4 g/0.5 g. №1 vial

Ingredients

Tazpen contains piperacillin and tazobactam as active ingredients. These components work synergistically to inhibit bacterial cell wall synthesis and protect piperacillin from degradation by certain beta-lactamases.

Dosage

The recommended dosage of Tazpen for adults is typically 4.5 g every 6 hours via intravenous infusion over 30 minutes. Dosage adjustments may be necessary based on the severity of the infection and renal function.

Indications

Tazpen is indicated for the treatment of moderate to severe infections caused by susceptible bacteria, including intra-abdominal infections, skin and soft tissue infections, and pneumonia.

Contraindications

Do not use Tazpen if you have a history of severe allergic reactions to beta-lactam antibiotics. Caution is advised in patients with a history of hypersensitivity reactions.

Directions

Tazpen should be reconstituted with the appropriate volume of compatible diluent as per the package insert. The reconstituted solution should be further diluted before administration.

Scientific Evidence

Studies have shown that the combination of piperacillin and tazobactam in Tazpen provides broad-spectrum coverage against various Gram-positive and Gram-negative bacteria. Clinical trials have demonstrated the efficacy of Tazpen in treating complicated infections.

Additional Information

It is important to monitor renal function in patients receiving Tazpen due to the risk of nephrotoxicity. Tazpen should be used with caution in patients with renal impairment to prevent adverse effects.

Pharmacological Effects: Tazpen exerts its antibacterial effects by inhibiting bacterial cell wall synthesis, leading to cell lysis and death. Tazobactam enhances the activity of piperacillin by protecting it from beta-lactamase enzymes, extending its spectrum of activity.

Comparative Effectiveness: Tazpen has demonstrated comparable efficacy to other beta-lactam/beta-lactamase inhibitor combinations in the treatment of various infections. Its broad-spectrum coverage and favorable safety profile make it a valuable option in clinical practice.