Teraflu (paracetamol, phenylephrine) powder for oral solution sackets №10

Description

Teraflu (paracetamol, phenylephrine) powder for oral solution sackets №10

Composition

active substances: paracetamol, phenyramine maleate, phenylephrine hydrochloride, ascorbic acid;

1 package contains paracetamol 325 mg, phenyramine maleate 20 mg, phenylephrine hydrochloride 10 mg, ascorbic acid 50 mg;

Excipients: sucrose, anhydrous citric acid, natural citric flavor,

sodium citrate dihydrate, calcium phosphate, malic acid, titanium dioxide (E 171), yellow sunset dye (E 110), quinoline yellow dye (E 104).

Dosage form

Powder for oral solution.

Main physical and chemical properties: loose, large white granules with yellow spots and the smell of citrus. Possible content of soft lumps.

Pharmacotherapeutic group

Analgesics and antipyretics. Paracetamol, combinations without psycholeptics.
ATX code N02B E51.

Pharmacological properties

Combination drug for the treatment of flu and cold symptoms.

• Paracetamol has analgesic, antipyretic and mild anti-inflammatory effects, which is mainly mediated by inhibition of prostaglandin synthesis in the central nervous system. It does not affect platelet function or hemostasis. The absence of peripheral inhibition of prostaglandins determines the important properties of the drug, such as the maintenance of protective prostaglandins in the gastrointestinal tract. Therefore, paracetamol can be taken in patients for whom peripheral prostaglandin inhibition is undesirable (eg patients with a history of gastrointestinal bleeding or elderly patients).
• Phenylephrine hydrochloride is a sympathomimetic amine that acts primarily on alpha-adrenergic receptors. When used in therapeutic doses to eliminate nasal congestion, the drug does not show a significant stimulating effect on beta-adrenergic receptors of the heart and a significant effect on the central nervous system. It is a well-known nasal decongestant and acts by vasoconstriction, reducing swelling and redness of the nasal mucosa.
• Pheniramine maleate is a blocker of H1-receptors, has an antiallergic effect, reduces the severity of local exudative manifestations, reduces tearing, rhinorrhea, itching in the eyes and nose. Reduction of general allergic symptoms is associated with respiratory diseases, which causes a moderate sedative effect. It also has an antimuscarinic effect.
• Ascorbic acid may be helpful in compensating for the body’s increased need for vitamin C during fever and flu.

Indications

Teraflu is used to treat the symptoms of infectious and inflammatory diseases, accompanied by high body temperature, chills, headache, sneezing, muscle pain, body aches, runny nose and nasal congestion.

Contraindications

Teraflu drug is contraindicated in patients with diabetes mellitus, sucrose or isomaltase deficiency, fructose intolerance, alcoholism, portal hypertension and hypersensitivity to the components of the drug.
Reception of Teraflu is unacceptable in combination with beta-blockers, tricyclic antidepressants and monoamine oxidase inhibitors. The drug is not prescribed for children under 12 years of age, women at the stage of pregnancy and lactation.
The drug is prescribed with caution to patients with arterial hypertension, severe forms of atherosclerosis of the coronary arteries, angle-closure glaucoma, congenital hyperbilirubinemia, pheochromocytoma, hyperthyroidism, blood diseases, prostatic hyperplasia, bronchial asthma, hepatic dehydrogenase deficiency;

Application during pregnancy and lactation

During clinical studies, it was found that Teraflu is safe for pregnant women and women at the lactation stage, however, its effect on the development of the fetus and newborn is poorly understood, therefore, it is used in the therapy of this category of patients in extremely important cases.
If the appointment of the drug is necessary for a woman at the lactation stage, then the patient is recommended to stop breastfeeding during therapy.

Method of administration and dosage

Teraflu is taken orally, after dissolving the drug in a glass of warm water. If necessary, a little sugar can be added to the glass with the preparation. Theraflu is taken in a dosage of one packet at a time. It is allowed to use no more than 3 packages per day, the minimum interval between taking the drug is 4 hours. If taking the drug for three days did not allow achieving the desired therapeutic effect, it is recommended to replace it with any other alternative remedy.

Overdose

An overdose of Teraflu is characterized by the development of epigastric pain, nephrotoxic and hepatotoxic action. In particularly severe cases, the development of liver failure, an increase in the activity of liver enzymes, hepatonecrosis, encephalopathy and coma are observed.
To eliminate the symptoms of an overdose, the patient is given gastric lavage, activated charcoal and symptomatic treatment are prescribed.

Side effects

Sometimes taking Teraflu is accompanied by the development of allergies, a decrease in the speed of psychomotor reactions, increased drowsiness, dizziness, dry mouth, abdominal pain, increased blood pressure, urinary retention, increased eye pressure.