Tetracycline hydrochloride (tetracycline hydrochloride) coated tablets 100 mg №20

Description

Tetracycline hydrochloride (tetracycline hydrochloride) coated tablets 100 mg №20

Composition

active ingredient: tetracycline hydrochloride;

1 tablet contains tetracycline hydrochloride 100 mg;

excipients: sugar, gelatin, calcium stearate, talc, potato starch, polysorbate, opadra II red 85F35289 (mixture of substances: polyvinyl alcohol, polyethylene glycol 3350, titanium dioxide (E 171), talc, carmine (E 120), charming red AC ( E 129), sunset yellow FCF (E 110)).

Dosage form

Coated tablets.

Basic physical and chemical properties: round-shaped, film-coated tablets, from raspberry to red-brown in color, with a smooth biconvex surface.

Pharmacological group

Antibacterial agents for systemic use. Tetracyclines.
ATX code J01A A07.

Pharmacological properties

Broad-spectrum tetracycline antibiotic. Active against gram-positive (staphylococci, including those that produce penicillinase; streptococci, pneumococci, clostridia, listeria, anthrax bacilli) and gram-negative bacteria (gonococci, bordetella, E. coli, enterobacteria, klebsiella, salmonella, shigella), and also spirochetes, rickettsia, leptospira, pathogens of trachoma, ornithosis. It is slightly active or inactive against Pseudomonas aeruginosa, Proteus, seration, acid-fast bacteria, most strains of the species Bacteroides fragilis, fungi, influenza viruses, poliomyelitis, measles. There is evidence of the effectiveness of tetracycline in cholera.

The mechanism of the antibacterial action of tetracycline is based on the inhibition of ribosomal protein synthesis of microbial cells.

At commonly used doses, tetracycline acts bacteriostatically.

Indications

Tetracycline is used in therapy of inflammatory and infectious diseases caused by tetracycline-sensitive microflora, such as bronchitis, pneumonia, tonsillitis, pleural empyema, cholecystitis, pyelonephritis, intestinal infection, endometritis, endocarditis, syphilis, prostatitis, brucellosis, gonorrhea, pus rickettsioses, trachoma, osteomyelitis, blepharitis, conjunctivitis, acne.
In addition, the drug is used to prevent the development of postoperative infectious complications.

Contraindications

Tetracycline hydrochloride is not prescribed for patients who have been identified as hypersensitive to tetracycline hydrochloride and related antibiotics. The drug is not used in the treatment of fungal infections and is not prescribed for pregnant and lactating women.
Particular care should be taken when prescribing the drug to patients who have renal failure, leukopenia and have a history of allergic reactions.
Due to the fact that strains resistant to tetracycline have been widespread recently, the drug is used very rarely.
Tetracycline is not used for children under 8 years of age because it can cause permanent discoloration of the tooth enamel.
When taking tetracycline for the prevention of hypovitaminosis, patients should take vitamins of groups K and B.
At the time of treatment with Tetracycline, the patient should refuse to use dairy products, since they prevent the adsorption of the antibiotic.

Application during pregnancy and lactation

Due to the fact that tetracycline hydrochloride is able to penetrate the placental barrier and cause hypoplasia of tooth enamel, inhibit the growth of bones of the fetal skeleton and change the color of the teeth for a long time and cause the development of fatty infiltration of the liver tissue, the use of tetracycline in the therapy of women at the stage of lactation and pregnancy is impossible.

Method of administration and dosage

Tetracycline hydrochloride is taken orally at 250 or 500 mg every 6 hours. The highest daily dose for adults is 4 g. Children who have turned 8 years old are prescribed the drug at 25 or 50 mg per kg of body weight every 6 hours.

Overdose

With oral administration of tetracycline in high doses, patients experience increased side effects. With local application of the drug, an overdose is impossible.

Side effects

In some patients, when taking tetracycline, there is the development of nausea, vomiting, abdominal pain, anorexia, stool disorders, dry mouth, glossitis, esophagitis, discoloration of teeth and tongue, increased activity of liver enzymes, dizziness, headaches, anemia, photosensitization and allergic reactions.