Thioctacid 600 HR (α-lipoic acid) coated tablets 600 mg. №100 vial

Description

Thioctacid 600 HR (α-lipoic acid) coated tablets 600 mg. №100 vial

Composition

active substance: thioctic acid (thioctic (α-lipoic) acid);

1 film-coated tablet contains 600 mg of thioctic (α-lipoic) acid;

Excipients: low-substituted hydroxypropylcellulose, hydroxypropylcellulose, magnesium stearate, hypromellose, macrogol 6000, titanium dioxide (E 171), talc, quinoline yellow (E 104), indigo carmine (E 132).

Dosage form

Film-coated tablets.

Main physical and chemical properties: yellow-green with a matte sheen biconvex oblong film-coated tablets.

Pharmacotherapeutic group

Drugs that affect the digestive system and metabolic processes. Thioctic acid.
ATX code A16A X01.

Pharmacological properties

This pharmaceutical agent belongs to a group of drugs used in the treatment of certain types of diseases of the digestive system and metabolic processes in the body.
The drug owes its effect to the main therapeutic component – thioctic (lipoic) acid. The name “thioctacid” is also found. This medicinal substance from the group of vitamin-like components is an endogenous antioxidant.
Thioctic acid is an important cofactor and coenzyme involved in the oxidative decarboxylation of alpha-keto acids. Excess blood sugar (hyperglycemia) causes the accumulation of products of accelerated glycolysis, which in turn causes a decrease in blood flow and hypoxia, as well as ischemic changes. As a result, free radicals accumulate, damaging peripheral nerves.
Thioctic acid causes a decrease in blood glucose levels. The level of glycogen in the liver also increases. Insulin resistance increases.
Takes part in the regulation of lipid and carbohydrate metabolism, stimulates cholesterol metabolism. It improves liver function, protects its resistance to the effects of free radicals and toxic substances.
It has hepatoprotective, hypolipidemic, hypocholesterolemic and hypoglycemic effects.

Indications

Thioctacid 600 HR tablets used for the treatment of paresthesias (nervous sensitivity disorders) with complications of diabetes mellitus in the form of diabetic polyneuropathy.

Contraindications

The drug in question is contraindicated for use in cases where the patient has severe hypersensitivity (allergy) to the main or to one of the auxiliary components.
Also contraindicated for people with fructose intolerance.
The intake of alcoholic beverages is strictly prohibited.

Application during pregnancy and lactation

This drug is contraindicated in the treatment of pregnant women.
If it is necessary to administer the drug during breastfeeding, then lactation should be suspended for the duration of treatment.

Method of administration and dosage

The drug Thioctacid 600 HR tablets is taken at 600 mg per day, half an hour before the morning meal.
The dose is taken in 2 capsules of 300 mg each or 1 capsule of 600 mg of thioctic acid.
If food is taken earlier than 30 minutes later, it will complicate the absorption of the drug.
If the paresthesias are intense, then treatment begins with the infusion of the drug, then switch to oral administration.
The duration of the treatment course is 1-2 months.
During the entire course of treatment, blood sugar levels should be measured regularly, since taking thioctic acid can cause its decrease and hypoglycemic attacks.
It is possible to reduce the dose of insulin administered, depending on the blood sugar level.
At the beginning of the treatment course, a short-term increase in paresthesias in the form of “goose bumps” is possible.

Overdose

Overdose can cause:

• nausea, vomiting;
• headache;
• hypoglycemia;
• shock, hemolysis.

When taken with alcohol – severe intoxication, up to death. It manifests itself in psychomotor agitation, convulsions, lactic acidosis.
Recommended gastric lavage, intake of enterosorbents, hospitalization, treatment of symptoms.

Side effects

In some cases, there may be some side effects in the form of:

• changes and disturbances in taste;
• nausea, vomiting, abdominal pain, diarrhea;
• lowering blood sugar levels, hypoglycemic conditions (dizziness, increased sweating, headaches and visual impairments);
• allergic reactions in the form of skin rash, allergic urticaria, itching, shortness of breath;
  eczema.