Timalin (extract of thymus) lyophilisate for solution for injections 10 mg. vials №10

Description

Timalin (extract of thymus) lyophilisate for solution for injections 10 mg. vials №10 

Composition

active substance: 1 vial contains dry purified extract of the thymus (thymus) of cattle in terms of polypeptides not less than 1.5 mg;

Excipient: glycine.

Dosage form

Lyophilisate for solution for injection.

Main physical and chemical properties: amorphous powder or porous mass of white or white with a yellowish tinge.

Pharmacotherapeutic group

Immunostimulants.
ATX code L03A X.

Pharmacological properties

The specified agent refers to preparations of immunomodulators of polypeptide origin.
The active ingredient is an extract of the thymus gland (thymus) obtained from cattle. The drug helps to restore the body’s immunological reactivity (reaction to pathogenic stimuli). When it enters the body, the active ingredient regulates the quantitative composition of B-lymphocytes and T-lymphocytes, as well as their ratio.
The drug is prescribed to stimulate immune responses at the cellular level. In this case, there is an increase in phagocytic activity (processes of active capture, apoptosis of pathogens with the participation of phagocytes). Under the influence of the drug, the processes of restoring hematopoiesis are stimulated, if they are subject to oppression and the metabolic processes in the cells are improved.

Indications

The drug Timalin is prescribed for the treatment of the following diseases:

• acute and chronic purulent-inflammatory diseases of bones and soft tissues;
• violation of regenerative processes (bone fractures, burns, frostbite, trophic ulcers, radiation tissue necrosis, gastric ulcer and duodenal ulcer);
• acute and chronic bacterial and viral infections, multiple sclerosis, atherosclerosis obliterans, rheumatoid arthritis;
• suppression of immunity and hematopoiesis after radiation therapy or chemotherapy, the use of large doses of antibiotics.

Contraindications

The drug in question is contraindicated for use in cases where the patient has severe hypersensitivity (allergy) to the main or to one of the auxiliary components.
The drug is contraindicated in the presence of autoimmune diseases.
In pediatrics, the drug is used starting from the neonatal period.

Application during pregnancy and lactation
This drug is not allowed to be used by pregnant women – only under strict indications determined by the attending physician.
If it is necessary to take the drug during breastfeeding, lactation is suspended.

Method of administration and dosage

The contents of the ampoule (vial) are dissolved in 1-2 ml of 0.9% sodium chloride solution.
The dosage regimen of the drug Timalin is determined by the clinical immunologist based on the clinical and laboratory examination of the patient.
The drug is administered intramuscularly daily in the following doses: adults and children from 14 years old – 5-20 mg (30-100 mg per course) for 3-10 days, depending on the severity of immunity disorders.
In children, the drug can only be used as directed and under the supervision of a physician in the presence of proven violations (suppression) of cellular immunity.
Intramuscularly administered daily to children under the age of 1 year – 1 mg; 1-3 years – 1-2 mg each; 4-6 years old – 2-3 mg each; 7-14 years old – 3-5 mg for 3-10 days, depending on the severity of immunity disorders. If necessary, a second course of treatment is carried out (after 1-6 months).

Overdose

In cases of overdose, there may be an increase in adverse reactions.

Side effects

The drug is usually well tolerated when used in the recommended doses.
The following disorders can be observed as side effects:

• allergic reactions, dyspeptic symptoms – nausea;
• skin rash;
• hyperemia;
• itchy skin;
• reactions at the injection site.