Thiocetam (thiazoic acid) solution for injection 5 ml. ampoules №10

Description

Thiocetam (thiazoic acid) solution for injection 5 ml. ampoules №10

Composition

active ingredients: 1 ml of solution contains morpholinium salt of thiazoic acid in terms of 100% substance – 25 mg, which is equivalent to 16.6 mg of thiazoic acid; piracetam – 100 mg;

excipient: water for injection.

Dosage form

Solution for injection.

basic physico-chemical properties: transparent colorless or slightly yellowish liquid.

Pharmacological group

Other psychostimulants and nootropics.
ATX code N06B X.

Pharmacological properties

Thiocetam belongs to the group of cerebroactive agents, exhibits nootropic, anti-ischemic, antioxidant and membrane-stabilizing properties. The pharmacological effect of the drug is due to the mutually potentiating action of thiazoic acid and piracetam.

Thiocetam accelerates the utilization of glucose in aerobic and anaerobic oxidation reactions, normalizes bioenergetic processes, stabilizes metabolism in brain tissues and increases the body’s resistance to hypoxia.

The drug inhibits the formation of reactive oxygen species, reactivates the enzymatic antioxidant system, especially superoxide dismutase, inhibits free radical processes in brain tissues during ischemia, improves the rheological properties of blood by activating the fibrinolytic system, stabilizes and reduces the zones of necrosis and ischemia, respectively.

Thiocetam increases the intensity of the metabolic GABA shunt and the concentration of GABA in ischemic tissues.

Thiocetam improves the integrative and cognitive activity of the brain, promotes the learning process, eliminates amnesia, increases short-term and long-term memory. Thiocetam eliminates the effects of stress (anxiety, phobias, depression, sleep disturbance), reduces the lag in the physical and mental development of premature babies.

Indications

Oral Thiocetam is used in the treatment of diseases associated with impaired coronary and cerebral circulation, such as:

• violation of metabolic processes and blood microcirculation in the brain, which have arisen against the
• background of craniocerebral trauma and chronic intoxication;
• cerebral atherosclerosis, accompanied by the development of cerebral, transient and chronic cerebral circulation disorders;
• ischemic and hemorrhagic stroke.

Thiocetam in solution for injection is used in the treatment of acute disorders of cerebral circulation that have arisen against the background of ischemic stroke. Also, its appointment is advisable in the treatment of speech disorders, decreased physical activity, emotional lability, mental and somatic disorders that have arisen after an ischemic stroke.
Thiocetam is used in the treatment of encephalopathies of various etiologies resulting from traumatic and toxic damage to the brain.

Contraindications

Thiocetam is not prescribed to patients who have acute renal failure and hypersensitivity to piracetam or thiotriazoline. The drug is not used to treat women at the stage of lactation and pregnancy, as well as in pediatric practice.
With caution, Thiocetam is prescribed to patients with hemostasis disorders, elderly patients, as well as those who suffer from diseases of the cardiovascular system.

Application during pregnancy and lactation

Breastfeeding and pregnancy are important contraindications for the prescription of Thiocetam.

Method of administration and dosage

Thiocetam in solution for injection is used for intravenous drip or intramuscular administration. In the treatment of hemorrhagic stroke or its consequences, Thiocetam is prescribed intravenously, 20 or 30 ml of the drug diluted in 100 ml of solution for infusion 1 time per day. The duration of therapy is 14 days.

Overdose

In case of an acute overdose of Thiocetam, patients develop sleep disturbance, increased irritability and irritability, dyspeptic disorders and pain in the epigastric region.
To eliminate the symptoms of acute overdose, the patient is prescribed appropriate symptomatic treatment.

Side effects

When taking Thiocetam in some patients, hyperexcitability, depression, insomnia, dyspeptic disorders, changes in body weight, abdominal pain, and abnormal stool occur.