$56.10
Manufacturer: Germany
Prevention and treatment of diabetic polyneuropathy.
Description
Thiogamma (α-lipoic acid) tablets 600 mg. №30
Composition
active substance: α-lipoic acid;
composition per 1 tablet: contains α-lipoic acid 600 mg;
Excipients: methylhydroxypropylcellulose, colloidal anhydrous silica, microcrystalline cellulose, lactose monohydrate, sodium carboxymethylcellulose, talc, dimethicone, magnesium stearate;
film coating: polyethylene glycols, methylhydroxypropylcellulose, talc, sodium dodecyl sulfate.
Dosage form
film-coated tablets, light yellow with lighter and darker (white) inclusions, oblong, biconvex, with a line on both sides. The color of the tablet at the break – light yellow.
Pharmacotherapeutic group
Drugs that affect the digestive system and metabolic processes. Thioctic acid.
ATX code A16A X01.
Pharmacological properties
Pharmacodynamics. α-lipoic acid is a substance that is synthesized in the body and acts as a coenzyme in the oxidative decarboxylation of α-keto acids; plays an important role in the process of energy production in the cell. Helps reduce blood sugar and increase the amount of glycogen in the liver. Lack or disruption of α-lipoic acid metabolism due to intoxication or excessive accumulation of some breakdown products (eg ketone bodies) leads to disruption of aerobic glycolysis. α-lipoic acid can exist in two physiologically active forms (oxidized and reduced), which are characterized by antitoxic and antioxidant effects. α-lipoic acid affects cholesterol metabolism, participates in the regulation of lipid and carbohydrate metabolism, improves liver function (due to hepatoprotective, antioxidant, detoxifying effects). α-lipoic acid is similar in pharmacological properties to B vitamins.
Indications
Thiogamma tablets is used to treat tissue sensitivity disorders in diabetic and alcoholic polyneuropathy.
Contraindications
Thiogamma is not prescribed for patients in whom the development of lactic acidosis is easily provoked. It is not used to treat patients prone to allergic reactions to thioctic acid administration, suffering from dehydration, severe impairment of the kidneys or liver, acute cerebrovascular accident, chronic alcoholism. In addition, the drug cannot be used to treat children, pregnant and lactating women in the acute period of myocardial infarction, as well as those patients who have a history of cardiovascular or respiratory failure in the stage of decompensation.
Application during pregnancy and lactation
Thiogamma is not prescribed for the treatment of women in the stage of lactation and pregnancy, since there is no clinical experience with the use of the drug for this category of patients.
Method of administration and dosage
The drug Thiogamma tablets in tablets for oral administration is taken once a day at 600 mg. The tablets are consumed regardless of food, along with a sufficient amount of liquid. Duration of treatment is from 1 to 4 months.
Overdose
When taking Thiogamma in excessive doses, the patient may experience headaches, dizziness, nausea, vomiting, upset stools and abdominal pain. If the patient accidentally took a large dose of pills, then he is recommended to perform a gastric lavage within two hours after taking the drug. To improve the patient’s condition, it is recommended to carry out symptomatic treatment and forced diuresis, which will help to remove the drug from the patient’s body as soon as possible.
Side effects
In some patients, after intravenous administration of Thiogamma in the form of a solution for infusion, convulsive twitching of certain muscle groups may occur.
When treating with Thiogamma tablets, sometimes patients experience taste disturbances, hemorrhagic rashes, diplopia, nausea, vomiting, and urticaria.
With rapid parenteral administration of the drug, respiratory depression and a feeling of pressure on the head may develop. Such phenomena disappear very quickly after a decrease in the rate of administration.
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