Trigan-D (paracetamol, dicyclomine) 500/20 mg. tablets №100

Description

Trigan-D (paracetamol, dicyclomine) 500/20 mg. tablets №100

Ingredients:

active substances: paracetamol, dicyclomine hydrochloride;

1 tablet contains paracetamol 500 mg, dicyclomine hydrochloride 20 mg;

excipients: sodium starch glycolate, polyvinylpyrrolidone, microcrystalline cellulose, silicon dioxide, colloidal anhydrous corn starch, magnesium stearate.

Medicinal form. Tablets.

White or off-white round tablets scored on one side with beveled edges and flat surface.

With regards to its pharmacotherapeutic grouping, this medication falls under analgesics and antipyretics, specifically being a paracetamol combination without psycholeptics bearing the ATX code N02B E51. The main benefits of taking it come from its dual action against both pain and spasms. Paracetamol itself possesses several characteristics that contribute towards these benefits such as analgesia, weak anti-inflammatory ability, and the ability to reduce fever levels. Its mechanism of operation includes inhibition of cyclooxygenase-1 along with some level of COX-2 inhibition across central nervous system areas as well as peripheral tissue spaces which leads to inhibited prostaglandin creation affecting thermoregulation related pain alteration.

Dicyclomine hydrochloride is recognized as a tertiary amine, which has the capability to display anticholinergic activity leading to lowered tone of smooth muscles.

This medication also works towards eliminating pain and blocking antagonistic activity. By selectively paralyzing M-cholinereactive structures, it obstructs the transmission of impulses from postganglionic cholinergic nerves to the effector organs they innervate.

Ultimately channeling relaxation in smooth muscles, this drug manifests an antispasmodic effect monitored in spasms occurring in various systems such as stomach, intestines, biliary tract, urogenital and vascular.

Indications.

Pain syndromes with a spastic component of various origins:

• headache;
• toothache;
• muscle pain, neuralgia;
• rheumatic pain of sciatica;
• renal colic;
• menstrual pain.

Contraindications.

Increased sensitivity to the components of Trigan-D (paracetamol, dicyclomine). Glaucoma tachycardia urinary tract obstruction benign prostatic hypertrophy with a tendency to delay urination myasthenia severe kidney and/or liver dysfunction glucose-6-phosphate dehydrogenase deficiency alcoholism blood diseases pronounced anemia leukopenia; dynamic intestinal obstruction, obstructive diseases of the gastrointestinal tract, urinary and biliary tract with impaired patency, peptic ulcer of the stomach or duodenum, reflux esophagitis; acute bleeding; congenital hyperbilirubinemia (Gilbert Dubin-Johnson and Rotor syndromes).

Dosage and Administration.

Trigan-D (paracetamol, dicyclomine) is taken orally with a small amount of liquid (200 ml).

Adults and children over 15 years of age: 1-2 tablets, depending on the severity of pain, from 1 to 4 times a day. When carrying out therapy for adults, it is advisable to start with four tablets per day. The maximum dose can be increased to 8 tablets per day, provided that it is well tolerated and there are no side effects

Children: 7 to 13 years: 1/2 tablet 1-2 times a day;

13 to 15 years: 1 tablet 1-3 times a day.

The duration of treatment is determined by the doctor individually, depending on the patient’s condition and reaction.