$25.30
Manufacturer: Netherlands
Infections caused by microorganisms sensitive to the drug: infections of the respiratory system and ENT organs; gastrointestinal infections; purulent infections of the skin and soft tissues; infections of the genitourinary system (gonorrhea, primary and secondary syphilis); typhus.
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Description
Unidox Soliutab (doxycycline) dispersible tablets 100 mg. №10
Composition
active ingredient: doxycycline;
1 tablet contains doxycycline in the form of doxycycline monohydrate 100 mg;
excipients: microcrystalline cellulose, saccharin, low-substituted hydroxypropyl cellulose, hypromellose, anhydrous colloidal silicon dioxide, magnesium stearate, lactose monohydrate.
Dosage form
Dispersible tablets.
Basic physical and chemical properties: round, biconvex tablets from light yellow – gray-yellow to brown with patches, with the inscription “173” embossed on one side, and a notch on the other side.
Pharmacological group
Antibacterial agents for systemic use. Tetracycline. Doxycycline. ATX code J01A A02.
Pharmacological properties
Doxycycline has a bacteriostatic effect; its antimicrobial effect is realized by inhibiting protein synthesis. The drug is effective against a wide range of gram-positive and gram-negative bacteria and other microorganisms.
Indications
- Unidox Soliutab is used to treat infections caused by susceptible strains of gram-positive and gram-negative microorganisms, and some other microorganisms:
Respiratory tract infections: pneumonia and other diseases of the lower respiratory tract caused by susceptible strains of Streptococcus pneumoniae, Haemophilus influenza, Klebsiella pneumonia, etc. Pneumonia caused by Mycoplasma pneumoniae. Treatment of chronic bronchitis, sinusitis.
- Urinary tract infections: infections caused by susceptible strains of the species Klebsiella, Enterobacter, as well as the bacteria Escherichia coli, Streptococcus faecalis, etc.
- Sexually transmitted diseases: infections caused by Chlamydia trachomatis, including complicated urethral and endocervical infections and infections of the rectum. Non-gonococcal urethritis caused by Ureaplasma urealyticum (T-mycoplasma). Soft chancre, inguinal granuloma, venereal granuloma. Unidox Soliutab is an alternative drug for the treatment of gonorrhea and syphilis.
- Skin infections: acne if antibiotic treatment is needed.
- Since Unidox Soliutab belongs to the group of tetracycline antibiotics, it can be used for infections caused by microorganisms sensitive to tetracyclines, namely:
- Ophthalmic infections: infections caused by susceptible bacteria Gonococci, Staphylococci and Haemophilus influenza. The infection that causes trachoma is not always cleared, which is confirmed by immunofluorescence analysis. For the treatment of paratrachoma, Unidox Soliutab can be used as monotherapy or in combination with other drugs.
- Rickettsial infections: Rocky Mountain spotted fever, typhus group, Q fever, Coxiella endocarditis, tick fever.
- Other infections: ornithosis, brucellosis (when used in combination with streptomycin), cholera, bubonic plague, epidemic reverse typhoid tick-borne reverse fever, tularemia; melioidosis; tropical malaria resistant to chloroquine and acute intestinal amoebiasis (when used in combination with amebicide).
- Unidox Soliutab is an alternative drug for the treatment of leptospirosis, gas gangrene and tetanus.
- Unidox Soliutab is indicated for the prevention of the following conditions: Japanese river fever, traveler’s diarrhea (caused by enterotoxigenic Esherihia coli), leptospirosis, malaria. Malaria prophylaxis should be carried out in accordance with current practice due to the possibility of developing resistance.
Contraindications
Contraindicated in case of individual hypersensitivity to tetracyclines, other substances of the drug. Not applicable for acute liver or kidney failure. Also, it is not prescribed in the treatment of children under 8 years old.
Application during pregnancy and lactation
Contraindicated because doxycycline interferes with fetal bone formation. Breastfeeding is stopped for the period of treatment.
Method of administration and dosage
In the first days of the acute course of the disease, the drug is prescribed in a larger dosage, gradually reducing it. 1st day of treatment – 200 mg once a day or 100 mg 2 times a day. From the second day, it is enough to take 100 mg once a day.
In severe infections, the patient takes 200 mg daily throughout the course of treatment. With gonorrhea, treatment according to this scheme lasts 5 days. Perhaps the appointment of 300 mg for 2-4 days. Treatment of syphilis, regardless of the stage – 300 mg per day for 10 days.
Typhoid fever can be cured with a single dose of 200 mg per day, with a mild form or with a low weight of the patient – 100 mg is enough.
Children over the age of 8 years and weighing more than 50 kg take the drug at the rate of 4 mg per 1 kg of body weight, in the following days of treatment – 2 mg per 1 kg of body weight.
For more convenient intake by children, it is permissible to take a tablet in a crushed form, diluted in a small amount of water.
Overdose
Overdose is characterized by nausea, vomiting, diarrhea, anorexia, headaches. A specific antidote has not yet been identified. It is necessary to wash the stomach, ensure the intake of sorbents, and prescribe the treatment of symptoms.
Side effects
Taking the drug can cause reactions from the gastrointestinal tract, dysphalgia, glossitis, enterocolitis. Candidiasis may develop. The reactions of the hematopoietic system are possible, namely, the manifestation of hemolytic anemia, thrombocytopenia, eosonophilia, and a decrease in the prothrombin index. The skin is able to react with a rash, erythema. In rare cases, an allergic reaction occurs, including urticaria, lupus, pericarditis.
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