$29.00
Manufacturer: Slovenia
Ursonost is indicated in patients with radio-negative, non-calcified gallbladder stones <20 mm in largest diameter for whom facultative cholecystectomy can be performed, including patients at high surgical risk through systemic disease, elderly patients from surgery.
Ursonost is prescribed to prevent the formation of gallstones in obese patients who plan to lose weight quickly.
Description
Ursonost (ursodeoxycholic acid) capsules 150 mg. №20
Composition
active substance: ursodeoxycholic acid;
1 capsule contains 150 mg or 300 mg of ursodeoxycholic acid;
Excipients: corn starch, magnesium stearate, colloidal anhydrous silica.
Dosage form
Capsules.
Main physical and chemical properties: hard gelatin capsule of white or almost white color, containing fine-grained powder of white or almost white color.
Pharmacological group
Means used to treat the liver and biliary tract.
ATX code A05A A02.
Pharacological properties
This is a remedy used in diseases of the biliary tract. Ursodeoxycholic acid is a component of human bile. It reduces the saturation of bile with cholesterol by inhibiting its absorption in the intestine, reducing its excretion into bile. This helps dissolve cholesterol calculi (stones). The effect of this drug in cholestatic processes and liver diseases is due to the relative replacement of detergent-like, lipophilic, toxic bile acids with non-toxic, cytoprotective, hydrophilic ursodeoxycholic acid, as well as the ability to improve the secretory capacity of hepatocytes, immunoregulatory processes.
Indications
Ursonost capsules is shown:
- for dissolution of X-ray-negative cholesterol stones (stones) in the gallbladder, no more than 15 mm in diameter (subject to the conditions of a functioning gallbladder);
- with gastritis caused by bile reflux;
- for the symptomatic treatment of biliary cirrhosis (primary) in the compensation phase.
Contraindications
Ursonost capsules can not be used:
- with calcified calculi;
- with intolerance to the components of the drug;
- with obstruction of the biliary tract (bladder duct, common bile duct);
- with radiologically confirmed presence of calculi;
- with acute inflammation of the gallbladder, biliary tract;
- in violation of the contractile function of the gallbladder, frequent biliary colic.
Application during pregnancy and lactation
There is no sufficient data on the use of this medication in pregnant women. In this regard, the use during this period is possible only by the decision of the doctor.
It is not known whether ursodeoxycholic acid penetrates into breast milk, therefore, Ursonost is not used during breastfeeding or is temporarily stopped.
Method of administration and dosage
Ursonost capsules is used internally.
UDCA should be used under medical supervision.
Capsules should be swallowed whole with liquid. It is necessary to observe the regularity of reception.
For patients whose body weight is less than 47 kg or who have difficulty swallowing capsules, it is recommended to use the drug in a different dosage form (for example, suspension).
- Dissolution of gallstones
The recommended dose for the treatment of Ursonost for radiopaque gallbladder stones is 8-10 mg / kg / day in 2 or 3 divided doses.
Control ultrasound of the gallbladder should be performed every 6 months during the first year of drug therapy. If the gallstones dissolve, the drug should be continued and an ultrasound scan should be performed every 1-3 months. In the majority of patients who ultimately had complete stone dissolution, partial or complete stone dissolution was observed at the first treatment evaluation. If partial dissolution of stones is not observed after 12 months of therapy with Ursonost, the likelihood of success is significantly reduced. - Prevention of stone formation
The recommended dose of the drug for the prevention of gallstones in patients planning rapid weight loss is 600 mg / day (300 mg 2 times a day).
Overdose
In cases of overdose, diarrhea may occur. Other manifestations of overdose are unlikely, since the absorption of ursodeoxycholic acid decreases with increasing dose and a large amount of it is excreted in the feces.
With the development of diarrhea, it is recommended to reduce the dose, and with persistent diarrhea, to stop therapy.
Overdose treatment is symptomatic. It is necessary to restore fluid balance, normalize electrolyte levels.
Side effects:
- digestive disorders: mushy stools, diarrhea, pain in the right hypochondrium, calcification of calculi, decompensation of liver diseases;
- hypersensitivity reactions: urticaria, skin rash.
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