Validol 0,06 g. #30 tablets

Description

Validol 0,06 g. #30 tablets

Active ingredient: Each tablet contains a solution of menthol in menthyl valerate ether – 60 mg

Excipients: Confectioner’s sugar, calcium stearate

Dosage form

Tablets

Main physicochemical properties:

Whole, correct, round cylinders with flat upper and lower surfaces and beveled edges, with a notch for division, white or white with a yellowish tinge in color, with a characteristic menthol odor and a cooling taste. Gray inclusions and a powdery coating are allowed on the surface of the tablets.

Pharmacological group

Cardiovascular drugs. ATX code C01EX

Pharmacological properties

Pharmacology

Validol has a calming effect on the central nervous system, as well as causes a moderate reflex vasodilating (coronary) effect by reflex irritation of the sensitive nerve (“cold”) receptors of the mucous membrane of the oral cavity. Stimulation of receptors is accompanied by the induction of the release of endorphins, enkephalins, dynorphins and other opioid peptides, which play an important role in reducing pain, normalizing vascular permeability and regulating other important mechanisms of functioning of the cardiovascular and nervous systems. Under the influence of the drug, physiologically active substances – histamine, kinins, etc. are released.

Pharmacokinetics

When applied sublingually, the drug is absorbed from the mucous membrane of the oral cavity. The therapeutic effect occurs after about 5 minutes.

After absorption, the drug is metabolized in the liver and excreted in the urine in the form of glucuronides.

Indications

Attacks of mild angina pectoris, neuroses, hysteria, seasickness and airsickness (symptomatic therapy) headache associated with the use of nitrates.

Contraindications

Hypersensitivity to the components of the drug. Severe arterial hypotension, acute myocardial infarction.

Interaction with other drugs and other types of interactions

Reduces the severity of headache caused by taking nitrates. Potentiation of sedative and antihypertensive effects is possible with simultaneous administration with other psychotropic and antihypertensive drugs, opioid analgesics, anesthetics and alcohol.

Special features of application

In cases where chest pain does not go away after taking the drug, it is imperative to see a doctor to rule out acute coronary syndrome.

The drug contains sugar, which should be taken into account by patients with diabetes.

Use during pregnancy or breastfeeding

The use of the drug during pregnancy and breastfeeding is possible if, in the doctor’s opinion, the expected positive effect for the mother outweighs the potential risk to the fetus / child.

Ability to influence the reaction rate when driving or operating other mechanisms

Care should be taken in the first hours after taking the drug when working with vehicles or such work that requires increased attention, as dizziness, drowsiness and a decrease in the speed of psychomotor reactions are possible.

Dosage and administration

Hold the Validol tablets in the mouth (under the tongue) until completely dissolved. The single dose for adults is 1-2 tablets, the daily dose is 2-4 tablets.

If necessary, the daily dose can be increased. The maximum daily dose is 600 mg.

Duration of treatment – up to 7 days.

Children

There is no experience with the use of the drug in children.