Zanidip (lercanidipine hydrochloride) coated tablets 10 mg. №98

Description

Zanidip (lercanidipine hydrochloride) coated tablets 10 mg. №98

Composition

active substance: 1 tablet contains 10 mg lercanidipine hydrochloride (equivalent to 9.4 mg lercanidipine) or 20 mg lercanidipine hydrochloride (equivalent to 18.8 mg lercanidipine);

Excipients: lactose monohydrate, microcrystalline cellulose, sodium starch glycolate (type A), povidone KZ0, magnesium stearate;

• shell for tablets with a dosage of 10 mg: a mixture for film coating (hypromellose, talc, titanium dioxide (E 171), macrogol 6000, iron oxide yellow (E 172));
• shell for tablets with a dosage of 20 mg: a mixture for film coating (hypromellose, talc, titanium dioxide (E 171), macrogol 6000, iron oxide red (E 172)).

Dosage form

Film-coated tablets.

Basic physical and chemical properties:

• tablets containing 10 mg of lercanidipine hydrochloride – film-coated tablets, yellow, round, biconvex, with a notch on one side;
• tablets containing 20 mg of lercanidipine hydrochloride – film-coated tablets, pink, round, biconvex, with a notch on one side.

Pharmacotherapeutic group

Selective calcium antagonists with a predominant effect on blood vessels. Dihydropyridine derivatives. ATX code C08C A13.

Pharmacological properties

Zanidip is an effective blocker of slow calcium channels. This agent selectively blocks the influx of calcium ions into the heart cells, as well as into smooth muscle cells and the vascular wall. Its prolonged antihypertensive effect is due to a direct relaxing effect on vascular smooth muscle, resulting in a decrease in total vascular peripheral resistance.

Indications for use

Zanidip coated tablets is used to treat essential hypertension of mild or moderate severity.

Contraindications

Zanidip has contraindications to use: hypersensitivity reactions to the components that are part of this tool, obstruction of the vessels leaving the left ventricle, unstable angina, congestive heart failure. Also, the drug should not be taken in patients with liver and kidney problems, if creatinine clearance <30 ml / min, patients who have suffered a myocardial infarction within 1 month, women of childbearing potential who are planning a pregnancy and do not use effective contraception, use concomitantly with cyclosporine , CYP ZA4 inhibitors, grapefruit juice, pediatric patients.

Use during pregnancy and breastfeeding

The use of Zanidip for pregnant women and during breastfeeding is contraindicated.

Method of application and dose

The use of Zanidip coated tablets for the treatment of essential hypertension in mild or moderate form, start with a dose of 10 mg once a day, preferably in the morning, about 15 minutes before meals. If necessary on the advice of a doctor, the dose is increased to 20 mg.
The dose of the drug should be increased gradually, as the maximum positive effect occurs after two weeks of treatment.
It is also possible to use the drug Zanidit in combination therapy with diuretics, b-blockers, ACE inhibitors.
The tablets should be taken whole, without chewing, with plenty of water.

Overdose

Signs of Zanidip overdose are: excessive peripheral vasodilation, hypotension, reflex tachycardia, myocardial infarction and angina. In case of these symptoms, it is necessary to use cardiovascular drugs, intravenous atropine, as well as during the day to monitor the patient’s hemodynamics.

Side effects

The use of the drug Zanidip 10 coated tablets can cause quite a number of side effects, the most common of which are headache, peripheral edema, dizziness, tachycardia, palpitations and hot flashes. In rare cases, side effects may include drowsiness, angina, epigastric pain, diarrhea, dyspepsia, nausea and vomiting, rash, myalgia, polyuria, asthenia, and fatigue.
In exceptional cases, other side effects are also possible with the use of the drug Zanidip: hypersensitivity, fainting, hypertrophic gingivitis, hypotension, increased levels of hepatic transaminases in the blood, increased frequency of urination, angina, chest pain, myocardial infarction.