Description

Zeffix (lamivudine) tablets 100 mg. №28

Ingredients

Active ingredient: Lamivudine 100 mg per tablet.

Dosage

Dosage: The usual dose is one Zeffix 100 mg tablet once a day.

Indications

Indications: Zeffix is indicated for the treatment of chronic hepatitis B in adults with evidence of active viral replication and either persistent elevations in serum aminotransferases or histologically active disease.

Contraindications

Contraindications: Zeffix is contraindicated in patients with known hypersensitivity to lamivudine or any component of the product.

Directions

Directions: Take Zeffix exactly as prescribed by your healthcare provider. Do not change your dose or stop taking Zeffix without first talking to your healthcare provider.

Scientific Evidence

Pharmacological Effects: Lamivudine, the active ingredient in Zeffix, is a nucleoside analogue that inhibits the reverse transcriptase enzyme of the hepatitis B virus. By doing so, it reduces viral replication and helps control the infection.

Clinical Trials: Clinical studies have shown that Zeffix is effective in reducing viral load and improving liver function in patients with chronic hepatitis B. In a study by Liaw et al., Zeffix demonstrated a significant reduction in viral DNA levels compared to placebo after 52 weeks of treatment.

Additional Information

Zeffix should be used with caution in patients with renal impairment, as dose adjustments may be necessary. It is important to regularly monitor liver function and viral load during treatment with Zeffix.

Prior to starting Zeffix, inform your healthcare provider about any other medications you are taking, as drug interactions may occur. Common side effects of Zeffix include headache, nausea, and fatigue.