Zentel (albendazole) suspension for oral use 400 mg/10 ml. vial №1

Description

Zentel (albendazole) suspension for oral use 400 mg/10 ml. vial №1

Composition

active substance: albendazole;

10 ml of suspension contain 400 mg of albendazole;

Excipients: aluminum-magnesium silicate, sodium carboxymethylcellulose, glycerin, polysorbate 80, sorbitan laurate, potassium sorbate, benzoic acid, sorbic acid, antifoam silicone 1510, saccharin sodium, orange flavoring, flavoring, flavoring, flavoring.

Dosage form

The suspension is oral.

Main physical and chemical properties: from white to cream color suspension with the smell of orange and vanilla.

Pharmacotherapeutic group

Anthelmintics. Means used in nematodes. Benzimidazole derivatives. ATX code P02C A03.

Pharmacological properties

Albendazole is an antiprotozoal and anthelmintic drug from the benzimidazole carbonate group. The drug acts on both intestinal and tissue parasites in the form of eggs, larvae and adult helminths. The anthelmintic action of albendazole is due to inhibition of tubulin polymerization, which leads to impaired metabolism and death of helminths.

Albendazole is active against the following intestinal parasites: nematodes – Ascaris lumbricoides, Trichuris trichiura, Enterobius vermicularis, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Cutaneus Larva Migrans; cestodes – Hymenolepis nana, Taenia solium, Taenia saginata; trematodes – Opisthorchis viverrini, Clonorchis sinensis; protozoa – Giardia lamblia (intestinalis or duodenalis).

Albendazole is active against tissue parasites, including cystic and alveolar echinococcosis, caused by invasion of Echinococcus granulosus and Echinococcus multilocularis, respectively. Albendazole is an effective treatment for neurocysticercosis caused by larval invasion of Taenia solium, capillary disease caused by Capillaria philippinensis, and gnathostomosis caused by invasion of Gnathostoma spinigerum.

Albendazole destroys cysts or significantly reduces their size (up to 80%) in patients with granular echinococcosis. After treatment with albendazole, the number of non-viable cysts increases to 90% compared with 10% in patients who did not undergo treatment. After the use of albendazole for the treatment of cysts caused by Echinococcus multilocularis, complete recovery was observed in a smaller proportion of patients, in most – improvement or stabilization of the condition.

Indications

Zentel suspension active against: Ascaris lumbricoides, Trichuris trichiura, Enterobius vermicularis, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Cutaneus Larva Migrans, Hymenolepsis nana, Taenia solium, Taenia saginata, Opisthorchisisisarini granulosus, Echinococcosus multilocularis, Taenia solium, Capillaria philippinensis, Gnathostoma spinigerum, Echinococcus multilocularis.
It is applied at the following states:

• hookworm;
• ascariasis;
• toxocariasis;
• enterobiosis;
• necatorosis;
• teniosis;
• opisthorchiasis;
• trichinosis;
• clonorchosis;
• strogiloidosis;
• echinococcosis of the lungs, peritoneum, liver;
• neurocysticercosis;
• cutaneous migrating larvae;
• giardiasis.

Contraindications

Zentel suspension is not used:

• if you are allergic to albendazole;
• in case of intolerance of auxiliary components;
• at defeat of a retina;
• during pregnancy / lactation;
• children under three years.

Method of application and dose

Zentel suspension is administered orally, during meals, with water.
In such invasions as trichinosis, ascariasis, nekatorosis, hookworm, enterobiosis, 400 mg (10 ml of suspension) is used once. It is recommended to repeat the drug after three weeks.
At defeat by skin migrating larvae – 400 mg once / day within three days.
In strongyloidiasis, teniosis is indicated to take 400 mg once / day for three days. The course of therapy should be repeated after three weeks.
In opisthorchiasis, clonorchosis is indicated 400 mg twice / day for three days.
In toxocariasis, the drug is used twice / day (morning, evening) in a daily dose of 10 mg / kg for twenty days.
In giardiasis, children from three to twelve years of age are given 400 mg once / day for five days.

Overdose

Signs of overdose: sleep disturbances, vomiting, visual disturbances, speech, visual hallucinations, indigestion, fatigue, tachycardia, dizziness, tremor, enlarged liver, loss of consciousness, discoloration of skin, saliva, urine, sweat, tear fluid, feces on orange or red-brown.
In case of overdose it is necessary to stop further administration of this drug, to carry out gastric lavage, to appoint symptomatic therapy.

Side effects

Abdominal pain, diarrhea, stomatitis, dry mouth, nausea, dizziness, vomiting, flatulence, liver dysfunction, muscle pain, drowsiness / insomnia, headaches, disorientation, hallucinations, decreased visual acuity, convulsions, confusion are possible , itchy skin, joint pain, skin rash, high blood pressure, fever, hives, dermatitis, angioneurotic edema, acute renal failure, menstrual disorders, jaundice, photosensitization, changes in the blood picture (leukopenia, thrombocytopenia).