Zentel (albendazole) tablets 400 mg. №1

Description

Zentel (albendazole) tablets 400 mg. №1

Composition 

active substance: albendazole;

1 tablet contains 400 mg of albendazole;

excipients: lactose monohydrate; corn starch; povidone; sodium lauryl sulfate; croscarmellose sodium; microcrystalline cellulose; saccharin sodium; magnesium stearate; dye FD&C yellow # 6 Aluminum Lake 20-24% FDA; vanilla flavoring; orange flavoring; passion fruit flavoring.

Dosage form

Tablets.

Main physical and chemical properties: mottled, dull orange, rounded, oblong biconvex tablets with a characteristic fruity odor with a score line on one side of the tablet and the ALB400 imprint on the other.

Pharmacotherapeutic group

Anthelmintics. Means used in nematodes. Benzimidazole derivatives. ATX code P02C A03.

Pharmacological properties

Albendazole (Zentel) is an antiprotozoal and anthelmintic drug from the benzimidazole carbonate group. The drug acts on both intestinal and tissue parasites in the form of eggs, larvae and adult helminths. The anthelmintic action of albendazole is due to inhibition of tubulin polymerization, which leads to impaired metabolism and death of helminths.

Albendazole (Zentel) is active against the following intestinal parasites: nematodes – Ascaris lumbricoides, Trichuris trichiura, Enterobius vermicularis, Ancylostoma duodenale, Necator americanus, Strongyloides stercoralis, Cutaneus Larva Migrans; cestodes – Hymenolepis nana, Taenia solium, Taenia saginata; trematodes – Opisthorchis viverrini, Clonorchis sinensis; protozoa – Giardia lamblia (intestinalis or duodenalis).

Albendazole (Zentel) is active against tissue parasites, including cystic and alveolar echinococcosis, caused by invasion of Echinococcus granulosus and Echinococcus multilocularis, respectively. Albendazole is an effective treatment for neurocysticercosis caused by larval invasion of Taenia solium, capillary disease caused by Capillaria philippinensis, and gnathostomosis caused by invasion of Gnathostoma spinigerum.

Albendazole (Zentel) destroys cysts or significantly reduces their size (up to 80%) in patients with granular echinococcosis. After treatment with albendazole, the number of non-viable cysts increases to 90% compared with 10% in patients who did not undergo treatment. After the use of albendazole for the treatment of cysts caused by Echinococcus multilocularis, complete recovery was observed in a smaller proportion of patients, in most – improvement or stabilization of the condition.

Indication

Intestinal forms of helminthiasis and skin syndrome Larva Migrans (short-term treatment with small doses): enterobiosis, hookworm and necatorosis, hymenolepidosis, teniosis, strongyloidiasis, ascariasis, trichocephaly, clonorchosis, larchosis, opisthorchiasis, opisthorchiasis in children.

Systemic helminth infections (long-term treatment with high doses):

• cystic echinococcosis (caused by Echinococcus granulosus):
  in case of impossibility of surgical intervention;
  before surgery;
  after surgery, if the preoperative treatment was short, if the prevalence of helminths is observed or live forms were found during the operation;
  after percutaneous drainage of cysts for diagnostic or therapeutic purposes;
  alveolar echinococcosis (caused by Echinococcus multilocularis).
• in inoperable disease, in particular in cases of local or distant metastases;
  after palliative surgery;
  after radical surgery or liver transplantation;
  neurocysticercosis (caused by larvae of Taenia solium).
• in the presence of single or multiple cysts or granulomatous brain damage;
  in arachnoid or intraventricular cysts;
  at racemic cysts;
  capillarosis (caused by Capillaria philippinensis), gnathostomosis (caused by Gnathostoma spinigerum and related species), trichinosis (caused by Trichinella spiralis and T. pseudospiralis), toxocariasis (caused by Toxocara canis and related species).

Contraindications
Zentel is not used:

• if you are allergic to albendazole;
• in case of intolerance of auxiliary components;
• at defeat of a retina;
• during pregnancy / lactation;
• children under three years.

Method of application and dose

Intestinal infections and skin syndrome Larva Migrans

Take the drug Zentel with food. It is desirable to apply at the same time of day. If recovery does not occur after 3 weeks, the doctor should prescribe a second course of treatment.

Some patients, especially children, may have difficulty swallowing the whole tablet, in which case the tablet can be chewed with a small amount of water or it can be crushed.

Use for adults and children over 3 years of age.

• Enterobiasis, hookworm, necatorosis, ascariasis, trichocephaly – adults and children over 3 years of age – 400 mg 1 time / day (1 tablet) once.
• Strongyloidiasis, teniosis, hymenolepidosis – adults and children over 3 years of age – 400 mg 1 time / day (1 tablet) for 3 days.
• At a hymenolepidosis the repeated course of treatment in the interval from the 10th to the 21st day after the previous course is recommended.
• Clonorchosis, opisthorchiasis – adults and children over 3 years – 400 mg 1 tablet 2 times a day for 3 days.
• Skin syndrome Larva Migrans – adults and children over 3 years – 400 mg 1 tablet 1 time per day for 1-3 days.
• Giardiasis only children aged 3 to 12 years – 400 mg 1 tablet 1 time per day for 5 days.

For children aged 2 to 3 years to use another form of the drug Zentel – a suspension for oral administration.

Overdose

Signs of overdose: sleep disturbances, vomiting, visual disturbances, speech, visual hallucinations, indigestion, fatigue, tachycardia, dizziness, tremor, enlarged liver, loss of consciousness, discoloration of skin, saliva, urine, sweat, tear fluid, feces on orange or red-brown.
In case of overdose it is necessary to stop further administration of this drug, to carry out gastric lavage, to appoint symptomatic therapy.

Side effects

Abdominal pain, diarrhea, stomatitis, dry mouth, nausea, dizziness, vomiting, flatulence, liver dysfunction, muscle pain, drowsiness / insomnia, headaches, disorientation, hallucinations, decreased visual acuity, convulsions, confusion are possible , itchy skin, joint pain, skin rash, high blood pressure, fever, hives, dermatitis, angioneurotic edema, acute renal failure, menstrual disorders, jaundice, photosensitization, changes in the blood picture (leukopenia, thrombocytopenia).