Zovirax (acyclovir) cream 5% 2 g. tube №1

Description

Zovirax (acyclovir) cream 5% 2 g. tube №1

Composition

active substance: 1 g of cream contains 50 mg of acyclovir;

Excipients: propylene glycol, white soft paraffin, mineral oil, cetostearyl alcohol, arlacel 165, poloxamer, sodium lauryl sulfate, dimethicone, purified water.

Dosage form

Cream.

Basic physical and chemical properties: cream from white to whitish color, homogeneous, without grains, lumps and foreign inclusions, without signs of stratification.

Pharmacotherapeutic group

Antiviral drugs. Acyclovir. ATX code D06B B03.

Pharmacological properties

Zovirax (acyclovir) is an antiviral drug that has high in vitro activity against herpes simplex virus types I and II. Toxic effect on the cells of the host organism is minimal. Once in the cells infected with the herpes virus, acyclovir is phosphorylated to form the active compound, acyclovir triphosphate. The first stage of this process depends on the presence of virus-encoded thymidine kinase. Acyclovir triphosphate acts as an inhibitor and substrate for viral DNA polymerase, preventing further synthesis of viral DNA without interfering with normal cellular processes.

Indication

Treatment of lip and facial infections caused by the herpes simplex virus (Herpes labialis).

Contraindication

Hypersensitivity to acyclovir, valacyclovir, propylene glycol or to other components of the cream.

Method of application and dosage

The drug is intended for external use.

Adults and children over 12 years of age: apply the cream 5 times a day at approximately 4-hour intervals, except at night. It is important to start treatment as soon as possible at the beginning of the infection, preferably during the prodromal period or at the stage of erythema. You can start treatment in the later stages – papules or blisters.

The treatment lasts at least 4 days. If healing does not occur, you can continue treatment for up to 10 days. If the symptoms of the disease do not disappear after 10 days of treatment, the patient should consult a doctor. Wash your hands before and after using the cream, and avoid excessive rubbing or touching the affected areas with a towel to prevent exacerbation or transmission of the infection.

Children

There are insufficient data on the safety of the drug in children under 12 years of age, so it is recommended for use in children under 12 years of age.

Overdose

Adverse drug effects after oral or topical administration of the entire contents of the tube are not expected due to minimal systemic exposure. In case of suspicion of overdose, seek medical attention.

Side effects

From the skin and connective tissues: temporary sharp or burning pain after applying the cream, moderate drying and peeling of the skin, itching.