Description
Allesta (Simvastatin) Tablets 20 mg. №30
Composition
Active ingredient: Simvastatin 20 mg.
Other ingredients: lactose monohydrate, microcrystalline cellulose, pregelatinized starch, and more.
Mechanism of Action
Simvastatin inhibits HMG-CoA reductase, an enzyme involved in cholesterol synthesis. By reducing cholesterol levels, it lowers the risk of cardiovascular events.
Pharmacological Properties
Simvastatin is a lipid-lowering agent that belongs to the statin class of drugs. It acts by decreasing the production of cholesterol in the liver, leading to reduced levels of LDL cholesterol and triglycerides in the blood.
Indications for Use
Indicated for: Lowering elevated levels of cholesterol and triglycerides in the bloodstream. It is also prescribed to decrease the risk of heart attack, stroke, and other cardiovascular complications in patients with diabetes or other predisposing factors.
Contraindications
Do not use if: You are pregnant, breastfeeding, have active liver disease, or are hypersensitive to simvastatin or any other components of the formulation.
Side Effects
Common side effects of Allesta may include muscle pain, weakness, gastrointestinal disturbances, and elevated liver enzymes. In rare cases, it may lead to rhabdomyolysis, a severe muscle condition.
Usage Instructions
Dosage: The typical dose is 20-40 mg once daily in the evening. Adjustments in dosage should be done at intervals of at least 4 weeks.
Administration: Swallow the tablet whole with a full glass of water. It is usually taken in the evening, with or without food, as directed by a healthcare professional.
Benefits Compared to Analogues
Compared to other lipid-lowering medications, Allesta has shown efficacy in reducing LDL cholesterol and cardiovascular events through established clinical trials.
Suitable Patient Groups
Allesta is suitable for adult patients with high cholesterol levels, individuals with diabetes at risk of cardiovascular complications, and those requiring lipid-lowering therapy to manage their lipid profile.
Storage and Shelf Life
Storage: Keep Allesta at room temperature, away from moisture and heat. Ensure it is stored out of the reach of children to prevent accidental ingestion.
Shelf Life: Check the expiration date on the packaging and do not use the product beyond this date.
Packaging Description
Allesta is available in a package containing 30 tablets of 20 mg strength each. The packaging is designed to maintain the integrity and stability of the tablets.
Clinical Evidence and Proven Effectiveness
Pharmacological Effects: Simvastatin’s mechanism of action in inhibiting cholesterol synthesis has been extensively studied and proven effective in reducing cardiovascular risk factors.
Clinical Studies: Research such as the Scandinavian Simvastatin Survival Study has demonstrated the significant benefits of simvastatin in lowering mortality and morbidity rates in high-risk patient populations.
Additional Information
Warnings: Before initiating Allesta therapy, inform your healthcare provider about any existing medical conditions or medications you are currently taking. Regular monitoring of liver function tests is advisable during treatment.
