Description
Cefepim (Cefepime) Powder for Injections 1000 mg. №1 Vial
Composition
The primary active ingredient in this product is Cefepime, which belongs to the fourth-generation cephalosporin antibiotics.
Mechanism of Action
Cefepime exerts its bactericidal effect by inhibiting bacterial cell wall synthesis through binding to essential penicillin-binding proteins (PBPs).
Pharmacological Properties
Cefepime demonstrates broad-spectrum activity against various Gram-positive and Gram-negative bacteria, including those resistant to other cephalosporins. It has enhanced stability against beta-lactamases, contributing to its efficacy.
Indications for Use
Cefepime is indicated for the treatment of severe infections caused by susceptible microorganisms, such as:
- Pneumonia
- Urinary tract infections
- Skin and soft tissue infections
- Intra-abdominal infections
Contraindications
Cefepime should not be administered to individuals with a known history of hypersensitivity to cephalosporin antibiotics. It is also contraindicated in patients with a history of immediate hypersensitivity reactions to penicillins.
Side Effects
Common side effects of Cefepime may include gastrointestinal disturbances, hypersensitivity reactions, and injection site reactions. Serious adverse effects such as Clostridium difficile-associated diarrhea and superinfections may occur.
Usage Instructions
Cefepime is intended for intravenous administration after reconstitution with a compatible diluent. The dosage and frequency should be determined by the severity of the infection and the patient’s renal function. It is crucial to follow the precise instructions provided by healthcare professionals.
Advantages Over Analogues
Cefepime exhibits a broader spectrum of activity and increased stability against beta-lactamases compared to earlier cephalosporins. Its extended half-life allows for less frequent dosing, enhancing patient compliance and convenience.
Suitable Patient Groups
Cefepime can be used in various patient populations, including adults, children, and the elderly. Dosing adjustments may be necessary based on age, renal function, and the specific infection being treated.
Storage and Shelf Life
Cefepime should be stored according to the manufacturer’s instructions, typically at controlled room temperature. The shelf life of the product should be checked before use, and expired vials must be discarded appropriately.
Packaging Description
The product is supplied as a single-dose vial containing 1000 mg of Cefepime powder for reconstitution. Each vial is labeled with the necessary information regarding dosage, composition, and storage requirements.
