Description
Depakin Chrono (Sodium Valproate) Coated Tablets with Prolonged Release 500 mg. №30
Ingredients:
Each coated tablet contains 500 mg of sodium valproate.
Mechanism of Action:
Sodium valproate works pharmacologically by increasing the levels of gamma-aminobutyric acid (GABA), a neurotransmitter that inhibits excessive neuronal activity. This mechanism helps in controlling seizures and stabilizing mood in patients with bipolar disorder.
Indications:
Depakin Chrono is indicated for the treatment of epilepsy and bipolar disorder. It helps control seizures and stabilize mood in patients with bipolar disorder.
Contraindications:
Do not use Depakin Chrono if you have liver disease, urea cycle disorders, or hypersensitivity to valproate or any components of the product.
Side Effects:
Common side effects of Depakin Chrono may include gastrointestinal disturbances, dizziness, drowsiness, and tremors. Serious side effects such as liver toxicity and blood disorders may also occur, requiring immediate medical attention.
Usage Instructions:
Swallow the tablets whole with a sufficient amount of water. Do not crush or chew the tablets. It is recommended to take the medication with food to reduce gastrointestinal side effects.
The usual starting dose for adults is 600 mg daily, divided into 2 doses. Dosage may be adjusted based on individual response.
Benefits Compared to Analogues:
Depakin Chrono offers the advantage of once-daily dosing with its prolonged release formulation, improving patient compliance and convenience. Compared to other antiepileptic drugs, sodium valproate has shown comparable efficacy in seizure control with a favorable side effect profile.
Suitable Patient Groups:
Depakin Chrono can be used in various patient groups including adults, children, and the elderly. However, dosing adjustments may be necessary based on age, weight, and individual response.
Storage Conditions and Shelf Life:
Store Depakin Chrono in a cool, dry place away from direct sunlight. Keep the tablets in their original packaging to protect them from moisture. Check the expiration date on the packaging and do not use the product after the specified date.
Packaging Description:
Depakin Chrono is available in blister packs containing 30 coated tablets of 500 mg each. The packaging is designed to ensure the stability and integrity of the tablets until use.
Scientific Evidence:
Depakin Chrono, containing sodium valproate, has been extensively studied for its efficacy in managing epilepsy and bipolar disorder. Research published in the Journal of Clinical Psychopharmacology demonstrated the effectiveness of sodium valproate in preventing manic episodes in patients with bipolar disorder. Additionally, a meta-analysis published in Epilepsia showed that sodium valproate is effective in reducing seizure frequency in patients with epilepsy.
Additional Information:
It is important to monitor liver function tests regularly during treatment with sodium valproate to detect any potential liver toxicity. Patients should be advised not to discontinue the medication abruptly, as it may lead to rebound seizures or mood swings.
Individual response to the medication may vary, and close monitoring by a healthcare provider is essential for optimal treatment outcomes.
