Description
Diroton (Lisinopril) Tablets 10 mg. №28
Composition
Active Ingredient: Each tablet contains Lisinopril 10 mg.
Mechanism of Action
Lisinopril, an angiotensin-converting enzyme (ACE) inhibitor, works by inhibiting the conversion of angiotensin I to angiotensin II. By blocking this enzyme, Lisinopril helps to relax blood vessels, lower blood pressure, and improve cardiac function.
Pharmacological Properties
Lisinopril exerts its antihypertensive and cardioprotective effects by reducing peripheral resistance, decreasing cardiac afterload, and preventing the negative remodeling of the heart muscle.
Indications for Use
Indications: Diroton is indicated for the management of hypertension to control blood pressure levels and for the treatment of heart failure to improve cardiac function.
Contraindications
Contraindications: Do not use Diroton if you have a known hypersensitivity to Lisinopril or any other ACE inhibitors. Avoid use during pregnancy, especially in the second and third trimesters, as it can cause fetal harm.
Side Effects
Common side effects of Diroton may include dizziness, persistent dry cough, headache, hypotension, and hyperkalemia. In rare cases, it may lead to angioedema or renal impairment.
Usage Instructions
Dosage: The typical initial dose of Diroton is 10 mg once daily. The dosage may be titrated based on individual blood pressure response. It is recommended to take the tablet with a full glass of water, with or without food.
Benefits Compared to Analogues
Diroton, containing Lisinopril as the active ingredient, offers advantages over other ACE inhibitors due to its long duration of action, once-daily dosing convenience, and proven efficacy in reducing cardiovascular events and mortality rates in heart failure patients.
Suitable Patient Groups
Diroton is suitable for adult patients with hypertension and heart failure. It may also be used in specific cases under close medical supervision for pediatric patients or the elderly, with dosage adjustments as necessary.
Storage and Shelf Life
- Storage: Keep Diroton at room temperature, protected from light, moisture, and excessive heat.
- Shelf Life: Check the expiration date on the packaging. Do not use expired tablets.
Packaging Description
Diroton is available in a package containing 28 tablets, each tablet marked with the strength of Lisinopril 10 mg.
Clinical Evidence and Proven Effectiveness
Lisinopril, the active component of Diroton, has been extensively studied for its efficacy in managing hypertension and heart failure. Clinical trials have consistently shown Lisinopril’s ability to reduce blood pressure, improve cardiac output, and enhance overall cardiovascular health.
Studies published in reputable journals, such as the Journal of the American College of Cardiology, have demonstrated that Lisinopril significantly reduces the incidence of cardiovascular events and mortality rates in heart failure patients when compared to a placebo group.
