Description
Fluconazol-TEVA (Fluconazole) Hard Capsules 100 mg. №10
Composition
Active Ingredient: Each capsule contains Fluconazole 100 mg.
Mechanism of Action
Fluconazole, the active ingredient in Fluconazol-TEVA, is a triazole antifungal agent that inhibits the fungal cytochrome P450 enzyme 14α-demethylase. This inhibition disrupts the synthesis of ergosterol, a crucial component of fungal cell membranes, leading to cellular leakage and ultimately fungal cell death.
Pharmacological Properties
Fluconazole exhibits fungistatic activity against a wide range of pathogenic fungi, including Candida species, Cryptococcus neoformans, and dermatophytes. It is well-absorbed orally and reaches therapeutic concentrations in various body tissues, making it effective in treating systemic fungal infections.
Indications for Use
- Treatment of vaginal yeast infections (vulvovaginal candidiasis)
- Oral thrush (oropharyngeal candidiasis)
- Esophageal candidiasis
- Cryptococcal meningitis
- Prophylaxis of fungal infections in immunocompromised patients
Contraindications
Avoid Fluconazol-TEVA in the following cases:
- Known hypersensitivity to fluconazole or other azole antifungals
- Co-administration with terfenadine, cisapride, or quinidine due to potential cardiac effects
- Pregnancy, especially during the first trimester
Side Effects
Common side effects of Fluconazol-TEVA may include nausea, headache, abdominal pain, and skin rash. In rare cases, severe hepatic reactions or anaphylaxis may occur. Monitoring liver function tests is recommended during prolonged therapy.
Usage Instructions
Dosage: The typical dose is one 100 mg capsule daily, with or without food, as directed by a healthcare professional. Dosage adjustments may be necessary in patients with renal impairment.
Benefits Compared to Analogues
Fluconazol-TEVA offers the advantage of once-daily dosing, simplifying treatment regimens and improving patient adherence compared to other antifungal agents. Its broad spectrum of activity and favorable safety profile make it a preferred choice in the management of various fungal infections.
Suitable Patient Groups
Fluconazol-TEVA is generally well-tolerated across different age groups, including pediatric and geriatric populations. Dosing in children should be based on weight and overall health status, while elderly patients may require dosage adjustments based on renal function.
Storage and Shelf Life
Store Fluconazol-TEVA in a cool, dry place away from moisture and sunlight. Keep the capsules in their original packaging to protect them from environmental factors. Check the expiration date on the blister pack and do not use the product after the specified date.
Packaging Description
Each pack of Fluconazol-TEVA contains 10 hard capsules, each encapsulating 100 mg of fluconazole. The blister pack is designed for convenient dosing and protection of the capsules from external influences.
Clinical Evidence and Proven Effectiveness
Fluconazol-TEVA has been extensively researched in clinical trials to establish its efficacy and safety in treating fungal infections. Studies, including those published in reputable journals like the Journal of Antimicrobial Chemotherapy, have consistently demonstrated the effectiveness of fluconazole in achieving high cure rates and improving patient outcomes.
Additional Information
Completing the full course of treatment with Fluconazol-TEVA is essential to prevent the development of drug-resistant fungi and ensure successful eradication of the infection. Patients should be educated on the importance of adherence to the prescribed regimen.
Prior to initiating treatment with Fluconazol-TEVA, healthcare providers should conduct a thorough review of the patient’s medication history to identify potential drug interactions. Caution is advised when co-administering fluconazole with certain medications that may lead to adverse effects or altered drug concentrations.
