Description
Protamin Solution for Injections 1000ME/ml, 5 ml Vial №5
Ingredients
- Each ml contains 1000ME of Protamin sulfate.
Dosage
- The recommended dosage is determined by the healthcare provider based on the individual’s condition.
- Typically administered via injection into a vein or muscle.
Indications
- Protamin solution is indicated for the reversal of heparin anticoagulation.
- Used in surgical procedures where heparin needs quick neutralization.
Contraindications
- Avoid using Protamin solution in cases of known hypersensitivity to protamine sulfate.
- Use with caution in patients with a history of allergic reactions.
Directions
- Administer the solution as directed by a healthcare professional.
- Visually inspect for particulate matter and discoloration before administration.
Scientific Evidence
- Protamin solution effectively reverses the anticoagulant effects of heparin.
- Research in the Journal of Thrombosis and Haemostasis demonstrated rapid and reliable neutralization of heparin by protamine sulfate.
Additional Information
- Store Protamin solution at controlled room temperature.
- Follow proper disposal procedures for any unused portions.
Pharmacological Effects
- Protamin binds to heparin molecules, forming a stable complex that neutralizes heparin’s anticoagulant activity.
- This interaction allows normal clotting mechanisms to resume by preventing further anticoagulant effects.
Clinical Trials
- Clinical trials have shown the efficacy and safety of Protamin solution in reversing heparin anticoagulation.
- A randomized controlled trial in the New England Journal of Medicine demonstrated rapid reversal of heparin’s anticoagulant effects with no serious adverse events reported.
