Description
Carboplatin Medak (Carboplatin) Concentrate for Infusions 10 mg/ml. 60 ml. Vial №1
Composition
The active ingredient in Carboplatin Medak is Carboplatin, with each 60 ml vial containing 600 mg of Carboplatin.
Mechanism of Action
Carboplatin is a platinum-containing compound that exerts its cytotoxic effect by forming DNA crosslinks, ultimately inhibiting DNA synthesis and cell proliferation.
Pharmacological Properties
Carboplatin Medak is a platinum coordination complex with antineoplastic activity. It undergoes hydrolysis to form reactive platinum complexes that bind to nucleophilic groups on DNA, leading to interstrand and intrastrand DNA crosslinks.
Indications for Use
Carboplatin Medak is indicated for the treatment of various cancers, including ovarian cancer, lung cancer, and testicular cancer.
Contraindications
- Severe renal impairment.
- History of severe allergic reactions to Carboplatin or other platinum-containing compounds.
- Severe bone marrow suppression.
Side Effects
Common side effects of Carboplatin Medak include myelosuppression, nausea, vomiting, and peripheral neuropathy. Serious side effects may include allergic reactions, renal toxicity, and neurotoxicity.
Usage Instructions
Carboplatin Medak is administered intravenously. The recommended dosage is 360 mg/m2 given over 15 to 60 minutes once every four weeks. It should be diluted with 5% Dextrose Injection or 0.9% Sodium Chloride Injection and should not be mixed with other medications during infusion.
Benefits Compared to Analogues
Carboplatin Medak offers a similar efficacy profile to other platinum-based chemotherapeutic agents while potentially providing a more favorable safety and tolerability profile in certain patient populations.
Suitable Patient Groups
Carboplatin Medak is suitable for use in adult patients with various types of cancer. Dosing adjustments may be required for pediatric or elderly patients based on individual factors and tolerability.
Storage and Shelf Life
Carboplatin Medak should be stored at controlled room temperature between 20°C to 25°C (68°F to 77°F). Protect from light. The shelf life of the product is typically stated on the packaging and should not be used beyond the expiration date.
Packaging Description
Carboplatin Medak is supplied in a 60 ml vial for intravenous infusion. Each vial is labeled with the product name, concentration, volume, and a unique identifier number for tracking and verification purposes.
