$32.10
Manufacturer: Germany
Out of stock
Description
Pharmacological properties of Actiferin (iron sulfate, serine)
Iron is essentialy important for the body: it is part of hemoglobin, myoglobin, various enzymes, reversibly binds oxygen and participates in redox reactions, stimulates erythropoiesis. Iron is also found in depot tissues (bone marrow, liver, spleen). The amino acid serine, which is part of Aktiferrin, promotes more efficient absorption of iron sulfate and its entry into the systemic circulation, which causes a rapid restoration of its content in the body to the required levels. This provides a better perception of the drug and allows you to reduce the required dose of iron.
Pharmacokinetics
Absorption. When ingested, about 10–15% of ferrous iron is generally absorbed in the duodenum and upper small intestine. In addition, with an increased intake of iron, passive transport of iron occurs in the body. Iron absorption increases significantly with iron deficiency in the body, as well as in case of increased erythropoiesis. The highest level of absorption (50-60%) is observed at low levels of hemoglobin and iron in the blood, and the intensity of absorption decreases again as these indicators normalize. Cmax of serum iron is achieved within 2-4 hours after taking the drug.
Distribution. In the blood, ferric iron binds to transferrin and is transported to the site of hemostasis or storage. At full saturation, total serum transferrin can bind a maximum of 12 mg of iron. This value is relatively small, and in the case of iron intoxication as a result of ingestion or parenteral administration, the iron-binding capacity of transferrin may decrease, leading to the release of free unbound iron, which is toxic, into the plasma. After binding to apoferritin, iron is deposited in the form of ferritin, in particular in the liver, spleen and bone marrow. Iron crosses the placental barrier and in small amounts into breast milk.
Withdrawal. Only about 1 mg of iron is excreted daily with dead cells of the skin and mucous membranes, with bile and urine. During menstruation, iron loss is about 1 mg/day. Most of the iron formed as a result of the breakdown of hemoglobin (20-30 mg / day) is used by the body to re-synthesise hemoglobin.
Indications
Aktiferrin is used for the treatment of iron deficiency in the body.
Application of Aktiferrin capsules
Aktiferrin should not be sucked, chewed or held in the mouth. Capsules must be swallowed whole with water. The drug is taken 30 minutes before meals or during a meal (depending on tolerance from the digestive tract), or with fruit juice containing ascorbic acid, which improves absorption in the small intestine. Taking with meals improves compatibility in the digestive tract.
The daily dose intake depends on the level of hemoglobin, body weight and age of the patient.
With oral administration of capsules, the daily dose is 1.3-4 mg of iron / kg of body weight.
Children aged 6-12 years: 1 capsule 1 time per day. Children aged >12 years: 1 capsule 2 times a day.
Adults, depending on the severity of the patient’s condition at the beginning of therapy, are prescribed 1 capsule 2-3 times a day, then, if long-term treatment is necessary, the dose is gradually reduced to 1 capsule 1 time per day.
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