Description

Pharmachologic effect
A drug that activates the metabolism in tissues, reduces tissue hypoxia, improves trophism and stimulates the regeneration process. It is a gemoderivate, which is obtained by dialysis and ultrafiltration (compounds with a molecular weight of less than 5000 daltons penetrate).

It has a positive effect on the transport and utilization of glucose, stimulates oxygen consumption (which leads to stabilization of the plasma membranes of cells during ischemia and a decrease in the formation of lactates), thus having an antihypoxic effect.

Actovegin not only increases the intracellular glucose content, but also improves oxidative metabolism, thereby improving the energy supply of the cell, as evidenced by an increase in the concentration of direct free energy carriers, such as ATP, ADP, phosphocreatine, as well as amino acids, such as glutamate, aspartate and GABA.

In case of disorders of metabolism and blood supply to the brain, for example, in the syndrome of cerebral insufficiency (dementia), the transfer of glucose through the BBB and its utilization by cells worsens. The activity of PDH and the concentration of acetylcholine also decrease. The use of Actovegin contributes to the normalization of these indicators, improves the transport and utilization of glucose, while an increase in oxygen consumption is observed.
Actovegin has been shown to act in the same way in peripheral (arterial, venous) circulatory disorders and the corresponding consequences of such disorders (arterial angiopathy, ulcerative lesions of the lower extremities), as well as when used to accelerate wound healing. With ulcers of various etiologies, trophic disorders (pressure sores), burns and radiation injuries, Actovegin improves not only morphological, but also biochemical parameters of granulation, for example, the concentration of DNA, hemoglobin and hydroxyproline increases.

The effect of Actovegin begins to appear no later than 30 minutes after ingestion and reaches a maximum after an average of 3 hours (2-6 hours).

Indications
As part of the complex therapy of metabolic and vascular disorders of the brain (various forms of cerebrovascular insufficiency, dementia, traumatic brain injury);
peripheral (arterial and venous) vascular disorders and their consequences (angiopathy, trophic ulcers).

Contraindications
hypersensitivity to the drug.
With caution, the drug should be prescribed for heart failure stage II-III, pulmonary edema, oliguria, anuria, overhydration, diabetes mellitus, hyperglycemia.

Side effects
Allergic reactions: urticaria, edema, drug fever.

Administration and dosage
Assign 1-2 tab. 3 times / day before meals.
The tablet is not chewed, washed down with a small amount of water.
The duration of treatment is 4-6 weeks.