Affida (ibuprofen) Max coated tablets 400 mg. №10

Description

Composition

active substance: ibuprofen;

• 1 tablet contains 400 mg of ibuprofen;

excipients: core: pregelatinized starch, microcrystalline cellulose, croscarmellose sodium, colloidal anhydrous silicon dioxide, talc, magnesium stearate;

shell: sucrose; acacia; white suspension: sucrose, acacia, titanium dioxide (E 171), talc, magnesium stearate, calcium carbonate, polyethoxylated castor oil, purified water; Opalux AS 1198 Pink: sucrose, titanium dioxide (E 171), erythrosine (E 127), sodium benzoate (E 211), purified water; Opaglos 6000 white: shellac, white wax, carnauba wax.

The main physical and chemical properties:

pink, round, convex tablets covered with a sugar coating.

Pharmacotherapeutic group

Non-steroidal anti-inflammatory and anti-rheumatic drugs. Derivatives of propionic acid. ATX code M01A E01.

Pharmacodynamics

Ibuprofen is a nonsteroidal anti-inflammatory drug (NSAID), a derivative of propionic acid, which has a targeted effect against pain, heat, and inflammation by inhibiting the synthesis of prostaglandins, mediators of pain and inflammation. In addition, ibuprofen reversibly inhibits platelet aggregation.

Experimental data show that ibuprofen can competitively suppress the effect of low-dose acetylsalicylic acid on platelet aggregation when these drugs are used simultaneously. Some pharmacodynamic studies have shown that single doses of 400 mg of ibuprofen within 8 hours before and within 30 minutes of immediate-release acetylsalicylic acid (81 mg) reduce the effects of aspirin (acetylsalicylic acid) on thromboxane formation or platelet aggregation. Although there is uncertainty regarding the extrapolation of these data to the clinical situation, the possibility that regular long-term use of ibuprofen may reduce the cardioprotective effect of low doses of acetylsalicylic acid cannot be excluded. With non-systematic use of ibuprofen, such a clinically significant effect is considered unlikely.

Indication

• Symptomatic treatment of headache, including migraine,
• toothache,
• dysmenorrhea,
• neuralgia,
• back pain
• joints, muscles,
• and also with symptoms of cold and flu.

Contraindications

• Hypersensitivity to ibuprofen or to any of the components of the drug.
• Hypersensitivity reactions (eg bronchial asthma, rhinitis, angioedema or urticaria) after the use of acetylsalicylic acid (aspirin) or other non-steroidal anti-inflammatory drugs (NSAIDs).
• History of gastrointestinal bleeding or perforation associated with NSAID use.
• Active gastric and duodenal ulcer disease or recurrences in history (two or more pronounced episodes of ulcer disease or bleeding).
• Severe hepatic impairment, renal impairment, heart failure (class IV according to the NYHA (New York Heart Association) classification).
• III trimester of pregnancy.
• Cerebrovascular or other bleeding.
• Disorders of hematopoiesis or blood coagulation.
• Severe dehydration.