Amicyl (Amikacin) 0.5 g. intravenous

active ingredient : amikacin;
1 bottle contains amikacin sulfate (1: 1.8) in terms of amikacin 0.5 g.

Lyophilisate for solution for injections.

Basic physical and chemical properties : porous mass of white or white color with a yellowish tint.

Antibacterial drugs for systemic use. Aminoglycosides. Amikacin.
ATX code J01G B06.

Amikacin is a semi-synthetic broad-spectrum aminoglycoside antibiotic. It has a bactericidal effect. Actively penetrating through the cell membrane of bacteria, it irreversibly binds to the 30S subunit of bacterial ribosomes, and inhibits protein synthesis of the pathogen.

Highly active against aerobic gram-negative bacteria: Pseudomonas aerugіnosa, Escherіchia coli, Shigella spp., Salmonella spp., Klebsіella spp., Enterobacter spp., Serratіa spp., Providencіa stuartіі.

It is also active against some gram-positive bacteria: Staphylococcus spp. (including strains resistant to penicillin, methicillin, some cephalosporins), some strains of Streptococcus spp.

Inactive against anaerobic bacteria.

Infections caused by amikacin-sensitive strains of microorganisms resistant to other aminoglycosides.

• Hypersensitivity to amikacin, to other components of the drug or to any other antibiotics of the aminoglycoside group and their derivatives;
• kidney failure;
• acoustic neuritis;
• myasthenia gravis;
• dysfunction of the vestibular apparatus;
• azotemia (residual nitrogen above 150 mg%);
• prior treatment with ototoxic or nephrotoxic drugs.

Apply Amycil intramuscularly or intravenously.

The usual doses for children over 12 years of age and adults are 5 mg/kg every 8 hours or 7.5 mg/kg every 12 hours. The maximum dose for adults is 15 mg / kg / day. In severe cases and infections caused by Pseudomonas, divide the daily dose into 3 doses. The maximum daily dose is 1.5 g. The maximum course dose should not exceed 15 g.

The duration of treatment with intravenous administration is up to 7 days, with intramuscular injection – 7-10 days.

For premature newborns, use at an initial saturation dose of 10 mg/kg of body weight, and then every 18–24 hours at 7.5 mg/kg for 7–10 days.

For full-term newborns and children under 12 years of age, first use 10 mg / kg body weight, then 7.5 mg / kg body weight every 12 hours for 7-10 days.

Patients with renal insufficiency require correction of the dosing regimen: dose reduction or increase in the intervals between injections without changing the single dose. Reduce the dose depending on the content of creatinine in the blood plasma and the patient’s body weight. The interval between antibiotic injections is calculated by multiplying the plasma creatinine level by 9; for example, if the creatinine level is 2 mg, the drug is administered every 18 hours.

Solution for parenteral administration should be prepared immediately before administration.

Amycil should be administered by intravenous infusion to adults and children using a volume of liquid sufficient for drip infusion over 60–90 minutes (at a rate of 50 drops per 1 minute), and for newborns within 1–2 hours.

For intravenous infusion, dissolve the contents of the vial in 100-200 ml of 0.9% sodium chloride solution or 5% glucose solution.

The concentration of amikacin solution for intravenous administration should not exceed 5 mg / ml. Intravenous jet injection of Amycil should be done very slowly (over about 7 minutes).

For intramuscular injections, dissolve the contents of the vial in 2-3 ml of water for injection and inject deeply into the upper outer quadrant of the buttock.