Description
Amlodipine Tablets 5 mg. №20
Ingredients:
Each tablet contains 5 mg of Amlodipine besylate.
Mechanism of Action:
Amlodipine is a dihydropyridine calcium channel blocker that inhibits the influx of calcium ions into vascular smooth muscle and cardiac muscle. By blocking calcium channels, it leads to vasodilation and decreased peripheral vascular resistance, resulting in reduced blood pressure.
Pharmacological Properties:
Amlodipine exerts its antihypertensive effects by selectively inhibiting calcium ion influx across cell membranes, particularly in vascular smooth muscle cells. This results in vasodilation and increased oxygen delivery to the heart muscle.
Indications for Use:
Amlodipine is indicated for the treatment of hypertension to lower blood pressure and reduce the risk of cardiovascular events. It is also used in the management of chronic stable angina to improve exercise tolerance.
Contraindications:
Do not use Amlodipine if you have a known hypersensitivity to amlodipine or other dihydropyridine calcium channel blockers. It is contraindicated in patients with severe hypotension, cardiogenic shock, and aortic stenosis.
Side Effects:
Common side effects of Amlodipine may include peripheral edema, headache, dizziness, flushing, and fatigue. In rare cases, it can lead to hypotension, palpitations, and gastrointestinal disturbances.
Usage Instructions:
The usual starting dose of Amlodipine is 5 mg once daily, which can be adjusted based on individual response. The maximum recommended dose is 10 mg once daily. It can be taken with or without food, as directed by a healthcare provider.
Benefits Compared to Analogues:
Amlodipine has shown superior efficacy in lowering blood pressure and reducing cardiovascular events compared to other antihypertensive agents. Its long-acting nature provides sustained blood pressure control with once-daily dosing.
Suitable Patient Groups:
Amlodipine is generally well-tolerated across different age groups, including the elderly and children over 6 years old. However, individual dosage adjustments may be necessary based on age, renal function, and comorbidities.
Storage Conditions and Shelf Life:
Store Amlodipine tablets at room temperature away from moisture and heat. Keep the medication in its original packaging to protect it from light. Check the expiration date on the packaging and do not use expired tablets.
Packaging Description:
Amlodipine tablets are typically packaged in blister packs of 20 tablets each. The packaging should include essential information such as the drug name, dosage strength, batch number, and expiration date for proper identification.
Clinical Evidence and Proven Effectiveness:
Amlodipine has been extensively studied in clinical trials, demonstrating its efficacy in lowering blood pressure and improving cardiovascular outcomes in patients with hypertension. Research published in the Journal of the American Medical Association highlighted the superior cardiovascular risk reduction with amlodipine compared to other antihypertensive medications.