Analgin-diabazol-papaverin (metamizole, bendazole, papaverine) tablets №10

active ingredients: metamizole sodium monohydrate, bendazole hydrochloride, papaverine hydrochloride;

1 tablet contains metamizole sodium monohydrate 250 mg, bendazole hydrochloride 20 mg, papaverine hydrochloride 20 mg;

excipients: potato starch, talc, povidone, magnesium stearate.

Pills.

Basic physical and chemical properties: tablets of white or white color with a yellowish tint, flat-cylindrical shape with a chamfer on one surface of the tablet, the trademark of the enterprise is applied, on the second surface of the tablet – risk.

Analgesics. Other analgesics and antipyretics. Pyrazolone. Metamizole sodium, combinations without psycholeptics.

ATX code N02B B52.

Combined drug with analgesic, antispasmodic and vasodilating effects due to the specific action of its components. The drug also has antihypertensive and antipyretic effects.

Metamizole sodium monohydrate – NSAIDs (NSAIDs) of the group of pyrazolone derivatives, has anti-inflammatory, analgesic and antipyretic effects. The mechanism of action is due to inhibition of cyclooxygenase (COX) and blocking the synthesis of prostaglandins from arachidonic acid, as well as a violation of the conduction of pain extra and proprioceptive impulses, an increase in the excitability threshold of thalamic centers of pain sensitivity, and an increase in heat transfer.

Bendazole hydrochloride has antispasmodic, vasodilating, hypotensive effects, and also has a stimulating effect on the functions of the spinal cord and helps restore the functions of peripheral nerves, has a moderate immunostimulating effect.

Papaverine hydrochloride has myotropic, antispasmodic, hypotensive effects. Blocks phosphodiesterase, causes the accumulation of cyclic adenosine monophosphate (cAMP) and a decrease in calcium in the cell, relaxes the smooth muscles of blood vessels and internal organs.

When taken orally, it is rapidly and completely absorbed. In the walls of the intestine, it is hydrolyzed to form an active metabolite. The action develops in 20-40 minutes and reaches a maximum after 2 hours. Metabolized in the liver. Excreted by the kidneys.

Pain associated with spasm of blood vessels or smooth muscles of internal organs.

Known or suspected hypersensitivity to any of the substances that make up Analgin Diabazol Papaverin (metamizole, bendazole), pyrazolone derivatives (butadione, tribuzone, antipyrine) suspicion of acute surgical pathology; diseases that occur with a decrease in muscle tone, convulsive syndrome; glaucoma, traumatic brain injury, severe heart failure, AV blockade, arterial hypotension, diabetes mellitus, hypothyroidism, adrenal insufficiency, prostatic hypertrophy, congenital deficiency of glucose-6-phosphate dehydrogenase, anemia of any etiology, cytostatic or infectious neutropenia, leukopenia, agranulocytosis , thrombocytopenia, hepatoporphyria, severe violations of the liver and kidneys, chronic nephritis with edema and impaired nitrogen excretion of the kidneys, bronchial asthma, respiratory depression, broncho-obstructive syndrome, gastric and duodenal ulcer, accompanied by bleeding; hypotonic colitis, habitual constipation, simultaneous use of MAO inhibitors (MAO). During pregnancy and breastfeeding. Childhood. Age 75 years (risk of hyperthermia).