Anticataral (paracetamol) powder №10

active ingredients: paracetamol, phenylephrine hydrochloride, chlorphenamine maleate;

1 sachet contains paracetamol 650 mg, phenylephrine hydrochloride 10 mg, chlorphenamine maleate 4 mg;

excipients: colloidal silicon dioxide, citric acid, sodium saccharin, sucrose, sodium cyclamate, orange flavor.

Powder for oral solution.

Basic physical and chemical properties: white homogeneous powder without lumps, after dissolving in water has an orange taste.

Analgesics and antipyretics. Paracetamol, combinations without psycholeptics.

ATX code N02B E51.

Combined drug with analgesic, antipyretic, anti-inflammatory and anti-allergic effects due to the effects of the ingredients of Anticataral (paracetamol).

Paracetamol is an analgesic-antipyretic, has a pronounced analgesic, antipyretic effect. The specified action of paracetamol is associated with its effect on the thermoregulatory center in the hypothalamus, the ability to inhibit the synthesis of prostaglandins in the central nervous system.

Phenylephrine hydrochloride – sympathomimetic, acts mainly by direct action on α-adrenergic receptors. Causes vasoconstriction, reduces swelling and hyperemia of the mucous membrane of the nasal cavity and paranasal sinuses.

Chlorphenamine maleate is an H1 receptor blocker, has an antiallergic effect, reduces capillary permeability, constricts blood vessels, eliminates swelling and hyperemia of the nasal mucosa, nasopharynx and paranasal sinuses; reduces local exudative manifestations, suppresses the symptoms of allergic rhinitis (sneezing, rhinorrhea, itchy eyes, nose, sore throat).

After oral administration, paracetamol is rapidly absorbed from the gastrointestinal tract. The maximum concentration in blood plasma is reached in 30-60 minutes. When used in therapeutic doses, the half-life is 1-4 hours. Paracetamol is metabolized in the liver mainly by means of a conjugation reaction. Depending on the plasma concentration, it is partially deacetylated or hydroxylated. The main route of excretion is in the urine (90-100% within 24 hours) in the form of conjugates of glucuronides (60%), sulfates (35%) or cysteine ​​(3%).

The elimination half-life of phenylephrine after oral administration is 2.1-3.4 hours.

The maximum concentration of chlorphenamine maleate in blood plasma is reached after 1-2.5 hours; the half-life is 16-19 hours. 70-83% of the oral dose is excreted in the urine unchanged or as metabolites.

Symptomatic treatment of influenza and acute respiratory infections accompanied by fever, sore throat, nasal congestion, runny nose, headache, muscle and joint pain, lacrimation.

Hypersensitivity to the components of Anticataral (paracetamol); severe liver and / or kidney disease; violation of hematopoiesis; blood diseases severe leukopenia, anemia severe cardiovascular diseases, including severe cardiac conduction disorders, severe coronary heart disease, severe arterial hypertension, decompensated heart failure, severe atherosclerosis of the coronary arteries congenital deficiency of glucose-6-phosphate dehydrogenase (may lead to hemolytic anemia); Gilbert’s syndrome (intermittent benign jaundice, resulting from a deficiency of glucuronyl transferase), Dubin-Johnson syndrome, emphysema, chronic obstructive pulmonary disease, bronchial asthma; diabetes mellitus, alcoholism, hyperthyroidism glaucoma; bladder neck obstruction; pyloroduodenal obstruction; peptic ulcer of the stomach in the acute stage; arrhythmias benign prostatic hyperplasia with difficulty urinating; acute pancreatitis hyperexcitability; sleep disturbance; pheochromocytoma; epilepsy old age; risk of respiratory failure.

Do not use together with MAO inhibitors (MAO) and within 2 weeks after the abolition of MAO inhibitors, tricyclic antidepressants, beta-blockers.