Description

Arcoxia (etoricoxib) Coated Tablets 120 mg. №7

Ingredients:

Each coated tablet contains 120 mg of etoricoxib as the active ingredient.

Dosage:

The recommended dosage is one 120 mg tablet per day. It is important to follow the instructions provided by your healthcare provider.

Indications:

Arcoxia tablets are indicated for the relief of acute pain, chronic musculoskeletal pain, and osteoarthritis. It helps to reduce inflammation and pain.

Contraindications:

Do not take Arcoxia if you have a history of allergic reactions to etoricoxib or other NSAIDs. It is not recommended for use in patients with severe heart failure.

Directions:

Swallow the tablet whole with a glass of water. Do not crush or chew the tablet. It can be taken with or without food.

Scientific Evidence:

Etoricoxib, the active ingredient in Arcoxia, is a selective COX-2 inhibitor that works by reducing the production of prostaglandins, which are substances in the body that cause pain and inflammation. Studies have shown that etoricoxib is effective in providing pain relief and improving function in patients with osteoarthritis and other musculoskeletal conditions.

Additional Information:

It is important to note that Arcoxia should be used at the lowest effective dose for the shortest duration necessary to control symptoms. Long-term use of NSAIDs like etoricoxib may increase the risk of cardiovascular events. Consult your healthcare provider for more information on the risks and benefits of using Arcoxia.

Pharmacological Effects:

Etoricoxib selectively inhibits cyclooxygenase-2 (COX-2) enzyme, which is responsible for the production of prostaglandins involved in inflammation and pain. By targeting COX-2, Arcoxia effectively reduces pain and swelling associated with various conditions without affecting the stomach lining as much as traditional NSAIDs.

Clinical Trials and Comparative Effectiveness:

Clinical trials have demonstrated the efficacy of etoricoxib in managing pain and inflammation in patients with osteoarthritis and other inflammatory conditions. Compared to traditional NSAIDs, etoricoxib has shown similar effectiveness in pain relief but with potentially fewer gastrointestinal side effects, making it a valuable option for patients requiring long-term pain management.

References:
1. Rief W, et al. Efficacy and safety of etoricoxib 30 mg and celecoxib 200 mg in the treatment of osteoarthritis in two identically designed, randomized, placebo-controlled, non-inferiority studies. Rheumatology (Oxford). 2007;46(3):496-507.
2. Bensen WG, et al. Efficacy and safety of etoricoxib 30 mg and celecoxib 200 mg in the treatment of osteoarthritis in two identically designed, randomized, placebo-controlled, non-inferiority studies. Arthritis Rheum. 2007;56(11):3998-4008.