$20.80
Manufacturer: Germany
Argett Duo (diclofenac) is used for symptomatic treatment of pain and inflammation in:
- rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, spondyloarthritis, pain syndrome of various localization, extra-articular rheumatism;
- edema with pain syndrome or post-traumatic inflammation.
Description
Argett Duo (diclofenac) capsules 75 mg, 20 pcs. – Instructions for use
Ingredients
active ingredient : diclofenac;
1 capsule contains 75 mg of diclofenac sodium (25 mg of diclofenac sodium in enteric form, 50 mg of diclofenac sodium in a form with prolonged action);
other ingredients: talc, microcrystalline cellulose, povidone K 25, anhydrous colloidal silicon dioxide, propylene glycol, ammonium methacrylate copolymer (type A), ammonium methacrylate copolymer (type B), methacrylate copolymer (type A) E 132), titanium dioxide ( E 171), sodium lauryl sulfate, printing ink (shellac, propylene glycol, titanium dioxide (E 171)).
Dosage form
Modified release capsules are rigid.
Basic physical and chemical properties: hard gelatin capsules size 2 with a white imprint “D75M” on the cap and body; capsule cap: light blue opaque; capsule body: colorless transparent; Contents of the capsule: granules from white to cream.
Pharmacotherapeutic group
Nonsteroidal anti-inflammatory and antirheumatic drugs; acetic acid derivatives and related substances. ATX code M01A B05.
Pharmacodynamics
Argett Duo (diclofenac) contains diclofenac sodium, a non-steroidal compound that has a pronounced anti-inflammatory, analgesic and antipyretic effect. The main mechanism of action of diclofenac is inhibition of prostaglandin biosynthesis. Prostaglandins play an important role in the genesis of inflammation, pain and fever.
In vitro, diclofenac sodium at concentrations equivalent to those achieved in the treatment of patients does not inhibit the biosynthesis of cartilage proteoglycans.
Indications
Symptomatic treatment of pain and inflammation in:
- rheumatoid arthritis, ankylosing spondylitis, osteoarthritis, spondyloarthritis, pain syndrome of various localization, extra-articular rheumatism;
- edema with pain syndrome or post-traumatic inflammation.
Contraindications
- Hypersensitivity to diclofenac, soy, peanuts or other ingredients of Argett Duo (diclofenac);
- stomach or intestinal ulcer, gastrointestinal bleeding or perforation;
- patients who, in response to taking acetylsalicylic acid or other non-steroidal anti-inflammatory drugs (NSAIDs), experience asthma attacks, urticaria or acute rhinitis;
- III trimester of pregnancy;
- proctitis, hemorrhoidal symptoms, rectal bleeding or other active bleeding;
- severe impairment of liver or kidney function;
- severe dysfunction of the heart;
- unexplained disorders of hematopoiesis;
- congestive heart failure (NYHAII-IV);
- coronary heart disease in patients with angina pectoris, myocardial infarction;
- cerebrovascular disease in patients who have had a stroke or have episodes of transient ischemic attacks;
- peripheral arterial disease;
- treatment of perioperative pain in coronary artery bypass grafting (or use of a heart-lung machine).
Dosage and administration
Argett Duo (diclofenac) is used for the treatment of adult patients starting with a daily dose of 75-150 mg, depending on the severity of symptoms. With mild symptoms, as well as with prolonged therapy, a dose of 75 mg / day is sufficient. If the symptoms of the disease are most pronounced at night or in the morning, Argett Duo should be used in the evening. The daily dose should not exceed 150 mg.
The drug should be used in the lowest effective doses for the shortest period of time, taking into account the task of treatment in each individual patient.
Take Argett Duo without chewing and drink plenty of liquid during or immediately after meals.
Elderly patients
No special dose adjustment is required, but the drug should be used with caution.
Impaired kidney function
Patients with mild to moderate renal impairment do not require a dose reduction.
Impaired liver function
Patients with mild to moderate hepatic impairment do not require a dose reduction.
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