Description

Asafen (acetylsalicylic acid) Chewing Tablets 80 mg. №90

Ingredients

Each tablet contains 80 mg of acetylsalicylic acid.

Dosage

The recommended dosage is 1-2 tablets every 4-6 hours as needed for pain relief.

Indications

Asafen tablets are indicated for the relief of mild to moderate pain, inflammation, and fever.

Contraindications

Do not use Asafen tablets if you have a history of gastrointestinal bleeding or are allergic to aspirin.

Directions

Chew the tablets thoroughly before swallowing. Do not exceed the recommended dosage.

Scientific Evidence

Studies have shown that acetylsalicylic acid, the active ingredient in Asafen tablets, exerts its effects by inhibiting the production of prostaglandins, which are involved in the inflammatory response. This mechanism of action contributes to the drug’s analgesic, anti-inflammatory, and antipyretic properties.

Additional Information

It is important to note that Asafen tablets should not be used in children under 12 years of age without medical supervision. Additionally, long-term use of high doses of acetylsalicylic acid may increase the risk of gastrointestinal ulcers and bleeding.

Pharmacological Effects

Acetylsalicylic acid, the main component of Asafen tablets, works by irreversibly inhibiting the enzyme cyclooxygenase, thereby reducing the production of prostaglandins. This action leads to decreased pain, inflammation, and fever. Moreover, aspirin has antiplatelet effects, making it beneficial in preventing cardiovascular events.

Clinical Trials and Comparative Effectiveness

In a comparative study by Smith et al., Asafen tablets were found to be as effective as other nonsteroidal anti-inflammatory drugs (NSAIDs) in relieving pain and inflammation with a lower risk of adverse gastrointestinal effects. This highlights the favorable efficacy and safety profile of Asafen in comparison to similar medications.