Description
Azibiot (Azithromycin) Coated Tablets 500 mg. №3
Composition
Each coated tablet contains 500 mg of Azithromycin as the active ingredient.
Mechanism of Action
Azithromycin, a macrolide antibiotic, exerts its bacteriostatic effect by binding to the 50S ribosomal subunit of susceptible microorganisms, thereby inhibiting protein synthesis and ultimately leading to bacterial cell death.
Pharmacological Properties
Azithromycin demonstrates broad-spectrum activity against various Gram-positive, Gram-negative, atypical, and anaerobic bacteria. It exhibits excellent tissue penetration and a prolonged half-life, allowing for once-daily dosing.
Indications for Use
- Treatment of respiratory tract infections caused by susceptible pathogens
- Management of skin and soft tissue infections
- Therapy for sexually transmitted diseases such as chlamydia
Contraindications
Azibiot tablets should not be administered to individuals with a known hypersensitivity to Azithromycin, other macrolides, or any component of the formulation. Caution is advised in patients with a history of hepatic dysfunction.
Side Effects
Common side effects may include gastrointestinal disturbances, such as nausea, vomiting, and diarrhea. Rarely, Azithromycin may lead to allergic reactions, hepatotoxicity, or cardiac arrhythmias. Monitoring for adverse events is recommended during therapy.
Usage Instructions
The typical dosage regimen for Azibiot tablets involves taking one 500 mg tablet orally once daily for a duration specified by the healthcare provider. The tablets should be swallowed whole with a sufficient amount of water.
Benefits Compared to Analogues
Azithromycin offers advantages over other antibiotics due to its extended tissue distribution, prolonged activity at the site of infection, and convenient once-daily dosing. These features contribute to enhanced patient adherence and improved treatment outcomes.
Suitable Patient Groups
Azibiot may be used in various patient populations, including adults, adolescents, and children over the age of 6 months. Dosing adjustments may be necessary in individuals with renal impairment based on creatinine clearance levels.
Storage and Shelf Life
Azibiot tablets should be stored at controlled room temperature away from moisture and light. The shelf life of the product is typically indicated on the packaging and should be adhered to for optimal efficacy.
Packaging Description
Azibiot tablets are typically supplied in blister packs containing a specified number of tablets per pack. The packaging is designed to maintain the stability and integrity of the product during storage and transportation.
Clinical Evidence and Proven Effectiveness
Azithromycin’s efficacy in treating bacterial infections has been well-documented in clinical studies. Notably, research published in the Journal of Antimicrobial Chemotherapy has highlighted the drug’s effectiveness against respiratory pathogens, supporting its use in clinical practice.
