Description

Calcium Folinate (Calcium Folinate) Solution for Injections 10 mg/ml. 20 ml. (200 mg.) Vial №1

Ingredients:

Each ml contains 10 mg of Calcium Folinate.

Dosage:

The dosage will be determined by a healthcare provider based on individual needs. It is usually administered by a healthcare professional through injection into a vein or muscle.

Indications:

Calcium Folinate is indicated for use as a rescue therapy to reduce the toxic effects of methotrexate or to enhance the efficacy of fluorouracil in cancer treatment.

Contraindications:

Do not use Calcium Folinate if there is a known hypersensitivity to folinic acid or any component of the product. It should not be used in patients with severe renal impairment.

Directions:

Follow the instructions provided by your healthcare provider for the correct administration of Calcium Folinate. It is important to not self-administer this medication.

Scientific Evidence:

Calcium Folinate, a form of folinic acid, plays a crucial role in DNA synthesis and repair. It is known to enhance the activity of fluorouracil by stabilizing the binding of the active metabolite to the enzyme thymidylate synthase. This mechanism leads to increased inhibition of thymidylate synthase, ultimately interfering with DNA synthesis in cancer cells.

Additional Information:

Calcium Folinate has been extensively studied in various clinical trials for its efficacy and safety profile. Research has shown that the combination of Calcium Folinate with fluorouracil significantly improves response rates and overall survival in patients with colorectal cancer compared to fluorouracil alone. Additionally, the use of Calcium Folinate as a rescue therapy in high-dose methotrexate regimens has been well-documented in reducing methotrexate toxicity without compromising the anti-cancer effects.

Overall, Calcium Folinate is a valuable adjunct in cancer therapy, offering a targeted approach to enhance the effectiveness of certain chemotherapeutic agents while minimizing associated toxicities. Its well-established pharmacological actions make it a cornerstone in the management of various malignancies, highlighting its importance in modern oncology practice.