Description

Co-Prenesa (perindopril tert-butylamine, Indapamide) tablets 4 mg/1.25 mg. №90

Ingredients

Active ingredients: Perindopril tert-butylamine 4 mg and Indapamide 1.25 mg.

Dosage

Dosage: The usual dose is one tablet taken once a day, preferably in the morning before a meal.

Indications

Indications: Co-Prenesa is indicated for the treatment of hypertension to lower blood pressure.

Contraindications

Contraindications: Do not use Co-Prenesa if you are allergic to any of the ingredients, have a history of angioedema related to previous ACE inhibitor therapy, or if you are pregnant.

Directions

Directions: Swallow the tablet whole with a glass of water. Do not crush or chew the tablet.

Scientific Evidence

Scientific evidence: Studies have shown that the combination of perindopril and Indapamide in Co-Prenesa is effective in lowering blood pressure and reducing the risk of cardiovascular events in patients with hypertension.

Additional Information

Additional Information: It is important to regularly monitor blood pressure and kidney function while taking Co-Prenesa to ensure optimal treatment outcomes.

Pharmacological Effects: Perindopril, an ACE inhibitor, works by blocking the conversion of angiotensin I to angiotensin II, leading to vasodilation and reduced aldosterone secretion. Indapamide, a thiazide-like diuretic, promotes diuresis and vasodilation, further lowering blood pressure.

Clinical Trials: Clinical trials have demonstrated the superior efficacy of the perindopril-Indapamide combination in reducing cardiovascular events compared to monotherapy with either drug alone.