Description

Co-Prenesa (perindopril tert-butylamine, Indapamide) tablets 8 mg/2.5 mg. №30

Ingredients

Active ingredients: Perindopril tert-butylamine, Indapamide

Dosage

Recommended dosage: 1 tablet daily, or as directed by a healthcare professional.

Indications

Co-Prenesa tablets are indicated for the treatment of hypertension to lower blood pressure.

Contraindications

Do not use Co-Prenesa tablets if you are allergic to any of the ingredients, have a history of angioedema related to previous ACE inhibitor therapy, or have severe renal impairment.

Directions

Take Co-Prenesa tablets orally with or without food, as directed by your doctor. Swallow the tablets whole with a full glass of water.

Scientific Evidence

Co-Prenesa tablets combine the ACE inhibitor perindopril with the diuretic Indapamide to provide a dual mechanism of action in lowering blood pressure. Perindopril works by inhibiting the angiotensin-converting enzyme, leading to vasodilation and reduced aldosterone secretion. Indapamide, a thiazide-like diuretic, promotes diuresis and vasodilation by inhibiting sodium reabsorption in the distal convoluted tubule.

Clinical trials have demonstrated the efficacy of perindopril and Indapamide in reducing cardiovascular events and mortality in hypertensive patients. The landmark study, ADVANCE (Action in Diabetes and Vascular Disease: Preterax and Diamicron MR Controlled Evaluation), showed a significant reduction in the risk of major macrovascular or microvascular events with this combination therapy.

Additional Information

It is important to monitor electrolytes and renal function periodically during treatment with Co-Prenesa tablets, especially in patients with renal impairment or elderly patients. Avoid concomitant use of potassium-sparing diuretics, potassium supplements, or salt substitutes containing potassium.

In conclusion, Co-Prenesa tablets offer a well-established combination therapy for hypertension with proven efficacy in reducing cardiovascular risk. Consult your healthcare provider for personalized recommendations and monitoring while using this medication.