Description
Combinil Duo (Cіprofloxacin Hydrochloride and Dexamethasone) Ear/Eye Drops 5 ml Vial
Ingredients
Each ml contains:
- Cіprofloxacin Hydrochloride: 3 mg
- Dexamethasone: 1 mg
Mechanism of Action
Combinil Duo exerts its effects through the antibacterial action of Cіprofloxacin, inhibiting bacterial DNA gyrase and topoisomerases, and the anti-inflammatory properties of Dexamethasone, which suppress inflammation by inhibiting multiple inflammatory cytokines.
Pharmacological Properties
The combination of Cіprofloxacin and Dexamethasone in Combinil Duo provides a synergistic effect, targeting both the infection-causing bacteria and the associated inflammation. Cіprofloxacin acts by interfering with bacterial DNA replication, while Dexamethasone reduces inflammation by inhibiting the release of inflammatory mediators.
Indications for Use
Combinil Duo is indicated for the treatment of bacterial infections in the eyes and ears, such as conjunctivitis and otitis externa. It is also effective in reducing inflammation and alleviating pain associated with these infections.
Contraindications
Do not use Combinil Duo if you are allergic to Cіprofloxacin, Dexamethasone, or any other ingredients in the product. Additionally, avoid using it if you have a viral or fungal infection in the eye or ear.
Side Effects
Common side effects of Combinil Duo may include temporary stinging or burning sensation upon application, blurred vision, or mild irritation. If you experience any severe or persistent side effects, discontinue use and consult a healthcare professional.
Usage Instructions
For adults and children over 1 year old:
Instill 1 to 2 drops into the affected eye(s) or ear(s) every 4 to 6 hours. Do not exceed 12 drops in 24 hours.
Benefits Compared to Analogues
Combinil Duo stands out from other similar products due to its dual action against bacterial infections and inflammation. The combination of Cіprofloxacin and Dexamethasone offers a more comprehensive treatment approach, leading to faster symptom relief and improved outcomes compared to using either drug alone.
Suitable Patient Groups
Combinil Duo is suitable for use in both pediatric and adult populations. However, special care should be taken when administering the product to children to ensure proper dosage and application technique.
Storage and Shelf Life
Store Combinil Duo vials tightly closed in a cool, dry place away from direct sunlight. Ensure that the product is kept out of reach of children. Check the expiration date on the packaging and do not use the product if it has expired.
Packaging Description
Combinil Duo is available in a 5 ml vial for convenient application. The packaging is designed to maintain the sterility and integrity of the product throughout its shelf life.
Scientific Evidence
Combinil Duo combines the antibacterial properties of Cіprofloxacin with the anti-inflammatory effects of Dexamethasone, providing a comprehensive treatment for bacterial infections in the eyes and ears. Studies have shown that the combination of these two active ingredients results in faster resolution of symptoms compared to using either drug alone.
Additional Information
It is crucial to complete the full course of treatment with Combinil Duo as prescribed by your healthcare provider, even if symptoms improve before the medication is finished. Avoid touching the dropper tip to prevent contamination and ensure proper storage conditions to maintain the product’s effectiveness.
