Description

Combogliza XR (saxagliptin, metformin) Coated Tablets 5 mg/1000 mg. №28

Ingredients:

Each tablet contains 5 mg of saxagliptin and 1000 mg of metformin.

Dosage:

The recommended dose is one tablet twice daily with meals.

Indications:

Combogliza XR is indicated for the treatment of type 2 diabetes mellitus. It helps control blood sugar levels by increasing insulin release and decreasing glucose production in the liver.

Contraindications:

Do not use Combogliza XR if you have severe kidney disease, metabolic acidosis, or a history of allergic reactions to saxagliptin or metformin.

Directions:

Take Combogliza XR exactly as prescribed by your healthcare provider. Do not exceed the recommended dosage. It is important to follow a healthy diet and exercise regimen while taking this medication.

Scientific Evidence:

Studies have shown that the combination of saxagliptin and metformin is effective in lowering HbA1c levels and improving glycemic control in patients with type 2 diabetes. Research published in the Journal of Clinical Endocrinology & Metabolism demonstrated the superior efficacy of saxagliptin/metformin combination therapy compared to metformin alone.

Additional Information:

Combogliza XR may cause side effects such as nausea, diarrhea, and hypoglycemia. It is important to monitor blood sugar levels regularly while taking this medication. Consult your doctor if you experience any adverse reactions.

Combogliza XR combines the benefits of saxagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, with metformin, a biguanide, to provide comprehensive management of type 2 diabetes. Saxagliptin works by increasing incretin levels, which stimulate insulin release and inhibit glucagon secretion, while metformin reduces hepatic glucose production and improves insulin sensitivity in peripheral tissues.

Clinical trials have shown that the saxagliptin/metformin combination offers better glycemic control and a lower risk of hypoglycemia compared to other antidiabetic agents. The synergistic effect of these two drugs makes Combogliza XR a valuable treatment option for patients with type 2 diabetes.