Description

Combogliza XR (Saxagliptin, Metformin) Coated Tablets 5 mg/1000 mg. №28

Ingredients:

Each tablet contains 5 mg of saxagliptin and 1000 mg of metformin.

Mechanism of Action:

Combogliza XR combines saxagliptin, a dipeptidyl peptidase-4 (DPP-4) inhibitor, with metformin, a biguanide. Saxagliptin increases incretin levels, stimulating insulin release and inhibiting glucagon secretion. Metformin reduces hepatic glucose production and enhances insulin sensitivity in peripheral tissues.

Pharmacological Properties:

Saxagliptin and metformin work synergistically to manage type 2 diabetes by regulating insulin and glucose levels through different mechanisms of action.

Indications for Use:

Combogliza XR is indicated for the treatment of type 2 diabetes mellitus. It helps control blood sugar levels by increasing insulin release and decreasing glucose production in the liver.

Contraindications:

Do not use Combogliza XR if you have severe kidney disease, metabolic acidosis, or a history of allergic reactions to saxagliptin or metformin.

Side Effects:

Possible side effects of Combogliza XR include nausea, diarrhea, and hypoglycemia. Regular monitoring of blood sugar levels is essential while taking this medication.

Usage Instructions:

The recommended dosage is one tablet twice daily with meals. Follow your healthcare provider’s prescription carefully and maintain a healthy diet and exercise routine.

Benefits Compared to Analogues:

Clinical studies have shown that the combination of saxagliptin and metformin in Combogliza XR provides better glycemic control and a reduced risk of hypoglycemia compared to other antidiabetic agents.

Suitable Patient Groups:

Combogliza XR is suitable for adult patients with type 2 diabetes who require comprehensive management of their condition. Consult a healthcare professional for appropriate use in specific patient populations such as children or the elderly.

Storage Conditions and Shelf Life:

Store Combogliza XR in a cool, dry place at room temperature. Keep it out of reach of children. Check the expiration date on the packaging and do not use the product beyond that date.

Packaging Description:

Combogliza XR is available in blister packs containing 28 coated tablets of 5 mg saxagliptin and 1000 mg metformin each.