Description

Coriol (carvedilol) tablets 3.125 mg. №28

Ingredients

Active ingredient: Carvedilol 3.125 mg per tablet.

Dosage

Dosage: The usual starting dose is 3.125 mg twice daily. Dosage may be increased gradually. Consult a healthcare professional for personalized dosing.

Indications

Indications: Coriol tablets are indicated for the treatment of hypertension, heart failure, and left ventricular dysfunction following myocardial infarction.

Contraindications

Contraindications: Do not use Coriol tablets if you have asthma, severe bradycardia, or heart block greater than first degree.

Directions

Directions: Take Coriol tablets orally with food. Do not crush or chew the tablets. Follow the instructions provided by your healthcare provider.

Scientific Evidence

Coriol (carvedilol) has been extensively studied for its efficacy in managing hypertension and heart failure. Clinical trials have demonstrated its ability to reduce blood pressure, improve cardiac function, and increase survival rates in patients with heart failure. A study published in the Journal of the American College of Cardiology showed that carvedilol significantly reduced the risk of cardiovascular mortality and hospitalizations in patients with heart failure.

Additional Information

It is important to regularly monitor blood pressure and heart rate while taking Coriol tablets. Inform your healthcare provider about any other medications or supplements you are taking to avoid potential drug interactions. If you experience any severe side effects such as difficulty breathing or swelling of the face, seek immediate medical attention.

Pharmacological Effects: Carvedilol is a non-selective beta-blocker that also has alpha-blocking activity. It works by blocking the action of certain natural substances in the body, such as epinephrine, on the heart and blood vessels. This results in decreased heart rate, reduced blood pressure, and improved heart function.

Clinical Trials: In a comparative effectiveness study published in JAMA Cardiology, carvedilol was found to be more effective than metoprolol in reducing the risk of heart failure hospitalizations and mortality. The study concluded that carvedilol may offer superior benefits in the management of heart failure.