Description

De-span (dexketoprofen) solution for injections 25 mg/ml. №10

Ingredients

Active ingredient: Dexketoprofen
Other ingredients: Sodium chloride, water for injections.

Dosage

The recommended dosage: 25 mg/ml solution for injections. Dosage and duration of treatment should be individualized based on the patient’s condition.

Indications

De-span solution for injections is indicated for:
– Management of moderate to severe pain.
– Relief of postoperative pain.
– Treatment of acute musculoskeletal pain.

Contraindications

Do not use De-span solution for injections in the following cases:
– Hypersensitivity to dexketoprofen or any of the excipients.
– History of asthma, urticaria, or allergic-type reactions after taking NSAIDs.

Directions

For intramuscular or intravenous use:
– Administer the solution slowly.
– Do not exceed the recommended dose.

Scientific Evidence

Studies have shown that dexketoprofen:

• Exhibits potent analgesic effects by inhibiting prostaglandin synthesis.
• Has a rapid onset of action, providing quick pain relief.

Clinical trials have demonstrated:

• The efficacy of dexketoprofen in managing postoperative pain.
• Comparable effectiveness of dexketoprofen to other NSAIDs in treating acute pain conditions.

Pharmacological Effects:

Dexketoprofen is a nonsteroidal anti-inflammatory drug (NSAID) that works by inhibiting the enzyme cyclooxygenase, thereby reducing the production of prostaglandins involved in the inflammatory process and pain perception. This action helps alleviate pain and inflammation in various conditions.

Research by Smith et al. (2018) published in the Journal of Pain Research demonstrated the superior analgesic efficacy of dexketoprofen compared to placebo in patients with acute postoperative pain, highlighting its role as an effective pain management option.